Thursday 31 December 2020

What to know about leukemia

 Leukemia is a cancer of the blood or bone marrow. Bone marrow produces blood cells. Leukemia can develop due to a problem with blood cell production. It usually affects the leukocytes, or white blood cells.

Leukemia is most likely to affect people over the age of 55 years, but it is also the most common cancer in those aged under 15 years.

The National Cancer Institute estimates that 61,780 people will receive a diagnosis of leukemia in 2019. They also predict that leukemia will cause 22,840 deaths in the same year.

Acute leukemia develops quickly and worsens rapidly, but chronic leukemia gets worse over time. There are several different types of leukemia, and the best course of treatment and a person’s chance of survival depends on which type they have.

In this article, we provide an overview of leukemia, causes, treatment, type, and symptoms.

Causes

Leukemia develops when the DNA of developing blood cells, mainly white cells, incurs damage. This causes the blood cells to grow and divide uncontrollably.

Healthy blood cells die, and new cells replace them. These develop in the bone marrow.

The abnormal blood cells do not die at a natural point in their life cycle. Instead, they build up and occupy more space.

As the bone marrow produces more cancer cells, they begin to overcrowd the blood, preventing the healthy white blood cells from growing and functioning normally.

Eventually, the cancerous cells outnumber healthy cells in the blood.

Source: Medical News Today

Wednesday 30 December 2020

Could telomere shortening protect against cancer?

 Researchers at Rockefeller University studied the TIN2 protein associated with telomere length. They found that telomere shortening — a sign of cellular aging — might help protect against cancer.

The Centers for Disease Control and Prevention (CDC) found that in 2017, over 1.7 million people in the U.S. developed cancer, while there were nearly 600,000 deaths.

Scientists have made great strides in cancer research over the past few decades, but continuing to learn more about how it functions is paramount to prevention and developing new therapies.

A new study that appears in eLife examines the connection between telomeres, the caps at the end of DNA strands, and cancer.

Source: Medical News Today

Tuesday 29 December 2020

Can a smile reduce the pain of an injection?

 A recent study finds that both smiling and grimacing could reduce the sensation of pain associated with a “vaccination-like needle injection.” A sincere smile also reduced stress-induced physiological responses in participants.

When humans face acute pain, they tend to close their eyes tightly, raise their cheeks, and bare their teeth. Certain animals use similar facial expressions, which experts often call the grimace response.

As the authors of the recent study explain, “these facial musculature changes can also have a different interpretation: smiling.”

Why these two expressions, which occur for very different reasons, should share so many aspects is unclear. Researchers from the University of California, Irvine School of Ecology recently set out to “test whether these facial movements are beneficial in the context of stress and pain.”

Specifically, they wanted to understand whether manipulating participants’ facial expressions during a needle injection might impact their experience of pain and associated stress levels.

The researchers’ findings appear in the journal Emotion.

For many years, scientists have been interested to understand the impact of facial expressions on pain perception and mood. The facial feedback hypothesis, for instance, states that activating facial muscles can enhance or reduce emotional experiences. These effects on emotion can occur even if researchers manipulate a participant’s facial muscles into an expression.

As the authors of the recent study explain, “feigning a smile, whether conscious or not, may alter emotions in a positive way.” 

Source: Medical News Today

Monday 28 December 2020

Is there more than one strain of the new coronavirus?

 

Since the emergence of the new coronavirus, called SARS-CoV-2, several researchers have proposed that there is more than one strain, and that mutations have led to changes in how infectious and deadly it is. However, opinions are divided.

All data and statistics are based on publicly available data at the time of publication. Some information may be out of date. Visit our coronavirus hub and follow our live updates page for the most recent information on the COVID-19 outbreak.

Genetic mutations are a natural, everyday phenomenon. They can occur every time genetic material is copied.

When a virus replicates inside the cell it has infected, the myriad of new copies will have small differences. Why is this important?

When mutations lead to changes in how a virus behaves, it can have significant consequences. These do not necessarily have to be detrimental to the host, but in the case of vaccines or drugs that target specified viral proteins, mutations may weaken these interactions.

Since the emergence of SARS-CoV-2, several research studies have highlighted variations in the virus’s genetic sequence. This has prompted discussion about whether or not there are several strains, if this has an impact on how easily the virus can infect a host, and whether or not this affects how many more people are likely to die.

Many scientists have called for caution. In this Special Feature, we summarize what researchers currently know about SARS-CoV-2 mutations and hear from experts about their views on what these mean for the pandemic.

Source: Medical News Today

Sunday 27 December 2020

Nutrition advice for adults during the COVID-19 outbreak

 Proper nutrition and hydration are vital. People who eat a well-balanced diet tend to be healthier with stronger immune systems and lower risk of chronic illnesses and infectious diseases. So you should eat a variety of fresh and unprocessed foods every day to get the vitamins, minerals, dietary fibre, protein and antioxidants your body needs. Drink enough water. Avoid sugar, fat and salt to significantly lower your risk of overweight, obesity, heart disease, stroke, diabetes and certain types of cancer.

Eat fresh and unprocessed foods every day

Eat fruits, vegetables, legumes (e.g. lentils, beans), nuts and whole grains (e.g. unprocessed maize, millet, oats, wheat, brown rice or starchy tubers or roots such as potato, yam, taro or cassava), and foods from animal sources (e.g. meat, fish, eggs and milk).

Daily, eat: 2 cups of fruit (4 servings), 2.5 cups of vegetables (5 servings), 180 g of grains, and 160 g of meat and beans (red meat can be eaten 1−2 times per week, and poultry 2−3 times per week).

For snacks, choose raw vegetables and fresh fruit rather than foods that are high in sugar, fat or salt.

Do not overcook vegetables and fruit as this can lead to the loss of important vitamins.

When using canned or dried vegetables and fruit, choose varieties without added salt or sugar.

Drink enough water every day

Water is essential for life. It transports nutrients and compounds in blood, regulates your body temperature, gets rid of waste, and lubricates and cushions joints.

Drink 8–10 cups of water every day.

Water is the best choice, but you can also consume other drinks, fruits and vegetables that contain water, for example lemon juice (diluted in water and unsweetened), tea and coffee. But be careful not to consume too much caffeine, and avoid sweetened fruit juices, syrups, fruit juice concentrates, fizzy and still drinks as they all contain sugar.

Eat moderate amounts of fat and oil

Consume unsaturated fats (e.g. found in fish, avocado, nuts, olive oil, soy, canola, sunflower and corn oils) rather than saturated fats (e.g. found in fatty meat, butter, coconut oil, cream, cheese, ghee and lard).

Choose white meat (e.g. poultry) and fish, which are generally low in fat, rather than red meat.

Avoid processed meats because they are high in fat and salt.

Where possible, opt for low-fat or reduced-fat versions of milk and dairy products.

Avoid industrially produced trans fats. These are often found in processed food, fast food, snack food, fried food, frozen pizza, pies, cookies, margarines and spreads.

Eat less salt and sugar

When cooking and preparing food, limit the amount of salt and high-sodium condiments (e.g. soy sauce and fish sauce).

Limit your daily salt intake to less than 5 g (approximately 1 teaspoon), and use iodized salt.

Avoid foods (e.g. snacks) that are high in salt and sugar.

Limit your intake of soft drinks or sodas and other drinks that are high in sugar (e.g. fruit juices, fruit juice concentrates and syrups, flavoured milks and yogurt drinks).

Choose fresh fruits instead of sweet snacks such as cookies, cakes and chocolate.

Avoid eating out

Eat at home to reduce your rate of contact with other people and lower your chance of being exposed to COVID-19. We recommend maintaining a distance of at least 1 metre between yourself and anyone who is coughing or sneezing. That is not always possible in crowded social settings like restaurants and cafes. Droplets from infected people may land on surfaces and people’s hands (e.g. customers and staff), and with lots of people coming and going, you cannot tell if hands are being washed regularly enough, and surfaces are being cleaned and disinfected fast enough.28/12/2020


Source: World Health Organisation

Saturday 26 December 2020

Metabolic syndrome: What you need to know

Metabolic syndrome refers to a set of disease risk factors that appear to increase the risk of cardiovascular disease and type 2 diabetes. It is also known as insulin resistance syndrome.

The syndrome is not a specific condition, but it groups together a set of risk factors that have been linked to a higher chance of developing cardiovascular disease and type 2 diabetes.

The American Heart Association (AHA) describe metabolic syndrome as a “cluster of metabolic disorders,” that includes high blood pressure, high fasting glucose levels, and abdominal obesity, which, combined, increase the risk of heart disease.

According to the AHA, a doctor will often consider metabolic syndrome if a person has at least three of the following five symptoms:

  1. Central, visceral, abdominal obesity, specifically, a waist size of more than 40 inches in men and more than 35 inches in women
  2. Fasting blood glucose levels of 100 mg/dL or above
  3. Blood pressure of 130/85 mm/Hg or above
  4. Blood triglycerides levels of 150 mg/dL or higher
  5. High-density lipoprotein (HDL) cholesterol levels of 40 mg/dL or less for men and 50 mg/dL or less for women

Having three or more of these factors signifies a higher risk of cardiovascular diseases, such as heart attack or stroke, and type 2 diabetes.

According to the AHA, a doctor will often consider metabolic syndrome if a person has at least three of the following five symptoms:

  1. Central, visceral, abdominal obesity, specifically, a waist size of more than 40 inches in men and more than 35 inches in women
  2. Fasting blood glucose levels of 100 mg/dL or above
  3. Blood pressure of 130/85 mm/Hg or above
  4. Blood triglycerides levels of 150 mg/dL or higher
  5. High-density lipoprotein (HDL) cholesterol levels of 40 mg/dL or less for men and 50 mg/dL or less for women

Having three or more of these factors signifies a higher risk of cardiovascular diseases, such as heart attack or stroke, and type 2 diabetes.

Diagnosis initially aims to identify those people who could be at risk of metabolic syndrome, but who may benefit from lifestyle modifications rather than drug treatments.

High blood glucose levels, high blood pressure, and lipid and cholesterol abnormalities can often be targeted early with lifestyle measures.

However, some people may already be using medication for some aspect of metabolic syndrome, such as high blood pressure, when they receive their diagnosis.

Losing weight, especially in the upper body can be an effective treatment.

Suggested measures for preventing and treating abnormal cholesterol and other aspects of metabolic syndrome include

  • eating a “heart-healthy diet” that is low in sugar, fat, and sodium.
  • taking regular exercise
  • avoiding smoking and reducing alcohol intake

The AHA suggest doing at least 150 minutes of moderate exercise each week. These can be broken up into 10-minute sessions. Brisk walking is a good way to start.

Drug treatment

If drug treatment is recommended, this is usually with metformin.

This can help certain high-risk groups, especially people with high blood glucose levels and those on the spectrum of obesity that is not manageable with dietary and lifestyle modifications.

Source: Medical News Today


Friday 25 December 2020

Study reveals how exercise improves metabolic health

 Intensive exercise boosts communication between skeletal muscles and fat tissue, fine-tuning metabolism and improving performance, research in mice and humans suggests. The finding may lead to new treatments for metabolic diseases associated with aging and obesity.

Researchers in Brazil have discovered that aerobic exercise triggers the release of signaling molecules into the bloodstream that free up more energy for use by the muscles.

Previous research has found that aging and obesity impair the production of these signaling molecules, known as microRNAs. This increases the likelihood of metabolic diseases, such as diabetes and dyslipidemia.

The good news is that exercise may help ward off these conditions by stepping up the production of certain microRNAs.

The new research appears in the journal Proceedings of the National Academy of Sciences of the United States of America.

Marcelo Mori and his colleagues at the University of Campinas Institute of Biology in São Paulo, Brazil, collaborated on a series of experiments with researchers at the University of Copenhagen in Denmark and Harvard University in Cambridge, MA.

They started by putting mice on a treadmill for 60 minutes per day for 8 weeks. As the mice became fitter, the researchers increased the speed and slope of the treadmill.

At the end of the training program, the researchers found a significant increase in the production of a protein called DICER in the animals’ fat cells. This increase correlated with reductions in the body weight of the mice and the amount of visceral fat in their abdomens.

DICER is an enzyme that allows fat cells, or adipocytes, to make microRNA signaling molecules. These in turn make more energy available to the muscles.

When the scientists repeated the experiment with genetically modified mice that were unable to make any DICER in their fat cells, the mice did not benefit as much from the training program.

Source: Medical News Today


Thursday 24 December 2020

Through my eyes: ‘Living my best life’ with sickle cell anemia

 I’ve always been a little obsessed with having a great quality of life. I guess it makes sense considering I was told from a young age that my life expectancy and quality of life would be low.

It also makes sense then, that I’ve always been precious about how I spend my time, especially the older I get. That’s why I gratefully celebrate every single birthday I have, because aging is a privilege that few recognize.

The serious child

The year was 1990, and we were living in Hamburg, Germany. I was only 3 years old then. My parents tell me this part of my story as I don’t really remember any of it.

Apparently, I had an unexplainable, persistent stomach ache. When the doctors eventually came back with a diagnosis, they said, “Your daughter has sickle cell anemia, the most severe form of sickle cell disease.”

My parents were devastated. My mum cried the whole day and night after the diagnosis.

Originally from Sierra Leone, West Africa, they had only heard and seen nightmare tales of the sufferings and sudden deaths of people with sickle cell anemia (SCA).

Based on what they knew then, my life expectancy was set at 21 years, while my quality of life was expected to be interrupted by frequent hospitalizations, looking malnourished, and being ill all the time.

The diagnosis truly took my parents by surprise, because they never knew they were both carriers of the sickle cell trait until I showed up with the full-blown condition.

SCA is an inherited blood disease that causes red blood cells to be sickle- or crescent-shaped instead of round. These sickle-shaped blood cells do not live as long as healthy cells and can get stuck in blood vessels, leading to chronic anemia and oxygen shortage as the blood flow is obstructed. This obstruction is known as a vaso-occlusive crisis, or pain crisis, and can lead to severe joint pain, vital organ damage, and even death.

Looking back on my childhood in Germany with SCA, all I remember are the rules I had to stick to, to avoid being hospitalized, and being raised to teach others around me about the illness to foster awareness, acceptance, and critical support when needed.

Source: Medical News Today

Wednesday 23 December 2020

Coronavirus vaccine: Everything you need to know

 SARS-CoV-2, the virus that leads to coronavirus disease 19 (COVID-19), has spread rapidly from the first known cases in China in December 2019 to countries around the world.

On March 10, 2020, the World Health Organization (WHO) reported that there were 113,702 confirmed cases of COVID-19 around the world, plus 4,012 deaths.

In response to this global health crisis, researchers are working on developing a coronavirus vaccine as soon as possible.

Learn more about vaccine development and the possible timeline in this article.

Development

Researchers striving to develop a coronavirus vaccine are working with different approaches, including:

  • whole virus vaccine
  • recombinant protein subunit vaccine
  • antibody vaccine
  • nucleic acid vaccine

The sections below will discuss these approaches in more detail.

Whole virus vaccine

Whole virus vaccines use weakened or dead forms of the virus that causes the disease.

They can be effective at providing immunity in the long run, but there is a risk that some people could develop symptoms of the illness due to the vaccination.

Reports state that Johnson & Johnson, Codagenix, and researchers at the University of Hong Kong are working on this kind of vaccine.

Recombinant protein subunit vaccine

Recombinant protein subunit vaccines do not carry the risk of causing an infection in people who receive them, because they do not contain any live pathogens.

Researchers are investigating whether or not they can make a recombinant protein subunit vaccine that targets a protein called spike (S-) protein. The new coronavirus uses the S-protein to attach to and infect cells.

Novavax, Clover Biopharmaceuticals, the University of Queensland, and a consortium led by Texas Children’s Hospital for Vaccine Development are using this approach to develop a coronavirus vaccine.

Antibody vaccine

Other researchers are investigating whether or not they can create a vaccine using antibodies from the SARS outbreak that began in 2002.

SARS has many similarities to COVID-19, as they are caused by related coronaviruses.

So far, scientists have shown that the antibodies that neutralize the SARS-causing virus can also limit how well the new coronavirus infects cells in laboratory studies.

Source: Medical News Today


Tuesday 22 December 2020

COVID-19 vaccine trials: Live updates

 COVID-19 is a respiratory disease caused by the SARS-CoV-2 virus.

  • Researchers across the globe are working to develop a vaccine.
  • Currently, there are 60 candidate vaccines on trial in 41 countries.
  • Today, there are 15 candidate vaccines in stage 3 clinical trials.
  • So far, 3 vaccines have been approved.
  • For general COVID-19 updates visit our live blog.

12/18/2020 11:05 GMT — How do mRNA vaccines work?

Both the Pfizer-BioNtech vaccine and the Moderna vaccine candidate utilize mRNA technology. In a recent article, Medical News Today took a deep dive into the science behind mRNA vaccines. We explain how they differ from other types of vaccines and discuss their stability and safety.

12/18/2020 10:20 GMT — Johnson & Johnson announce phase 3 clinical trial

Johnson & Johnson recently announced a multicountry phase 3 clinical trial of their COVID-19 vaccine candidate. The company have already enrolled around 45,000 participants and, if the vaccine proves safe and effective, they will look for emergency use authorization from the Food and Drug Administration (FDA) in February 2021.

Data from the trial, called ENSEMBLE, could be available by the end of January 2021.

In contrast to the Pfizer-BioNTech and Moderna vaccines, the Johnson & Johnson offering only requires one dose. However, in parallel to ENSEMBLE, the company are running a phase 3 clinical trial called ENSEMBLE 2, which is investigating a two-dose regimen of Janssen.

Source: Medical News Today

Monday 21 December 2020

How do mRNA vaccines work?

 Most vaccines contain an infectious pathogen or a part of it, but mRNA vaccines deliver the genetic instructions for our cells to make viral or bacterial proteins themselves. Our immune system responds to these and builds up immunity.

Messenger RNA (mRNA) is a single-stranded molecule naturally present in all of our cells. It carries the instructions for making proteins from our genes, located in the cell nucleus, to the cytoplasm, the main body of our cells.

Enzymes in the cytoplasm then translate the information stored in mRNA and make proteins.

An mRNA vaccine delivers the instructions for making a bacterial or viral protein to our cells. Our immune system then responds to these proteins and develops the tools to react to future infections with the pathogen.

mRNA vaccine technology is not new, but there were no mRNA vaccines that had approval for use in humans until recently.

Some vaccines use a whole virus or bacterium to teach our bodies how to build up immunity to the pathogen. These pathogens are inactivated or attenuated, which means weakened. Other vaccines use parts of viruses or bacteria.

Recombinant vaccine technology employs yeast or bacterial cells to made many copies of a particular viral or bacterial protein or sometimes a small part of the protein.

mRNA vaccines bypass this step. They are chemically synthesized without the need for cells or pathogens, making the production process simpler. mRNA vaccines carry the information that allows our own cells to make the pathogen’s proteins or protein fragments themselves.

Importantly, mRNA vaccines only carry the information to make a small part of a pathogen. From this information, it is not possible for our cells to make the whole pathogen.

Both mRNA COVID-19 vaccines that Pfizer/BioNTech and Moderna have developed cannot cause COVID-19. They do not carry the full information for our cells to make the SARS-CoV-2 virus, and therefore, cannot cause an infection.

While the concept of mRNA vaccines may seem simple, the technology is rather sophisticated.

Source: Medical News Today

Sunday 20 December 2020

What is the protective value of different face masks?

 Researchers have assessed how effective various medical and consumer-grade masks are at protecting the wearer from exposure to particles similar in size to SARS-CoV-2.

In a new study, scientists have analyzed how effective consumer-grade masks, medical masks, and modified medical masks are at protecting the wearer from particles of a similar size to SARS-CoV-2.

The research, which appears in the journal JAMA Internal Medicine, provides more information for the public and clinicians on which masks to wear, and what modifications are likely to be effective.

SARS-CoV-2, the virus that causes COVID-19, primarily infects a person’s respiratory tract. As the infection develops, a high amount of the virus builds up in a person’s saliva and other respiratory secretions.

This explains a fundamental way in how the virus spreads: being ejected from a person with the infection via their nose or mouth as they talk, sing, sneeze, or cough. Wearing masks to interrupt this route of transmission has been increasingly recommended by scientists, clinicians, and government agencies.

For example, according to Dr. Robert R. Redfield, Director of the Centers for Disease Control and Prevention (CDC), “[c]loth face coverings are one of the most powerful weapons we have to slow and stop the spread of the virus — particularly when used universally within a community setting.”

“All Americans have a responsibility to protect themselves, their families, and their communities,” he emphasizes.

Experts believe face masks effectively reduce viral transmission because they block a person from expelling the virus and help prevent a person from receiving the expelled virus.

The protective effects of face masks are important for medical professionals, who are particularly vulnerable to the virus due to their high rates of exposure while working in clinical settings.

Many clinicians have access to medical procedure masks, while individuals sometimes modify them with the intention of boosting their ability to block viral transmission. However, it is not clear which modifications are the most effective.

Members of the public have access to a wide variety of masks, including home-made and improvised variants. Understanding which types of face coverings are most effective at blocking the virus is important as it enables people to increase their protection against the virus.

Source: Medical News Today

Saturday 19 December 2020

What are stem cells and why are they important?

 The idea of a miracle cure and bodies healing themselves holds a particular fascination. Stem cell research brings regenerative medicine a step closer, but many of the ideas and concepts remain controversial. So what are stem cells, and why are they so important?

Stem cells are a type of cell that can develop into many other types of cell. Stem cells can also renew themselves by dividing, even after they have been inactive for a long time.

The human body requires many different types of cell to function, but it does not produce each cell type fully formed and ready to use. Instead, it produces stem cells that have a wide range of possible functions. However, stem cells need to become a specific cell type to be useful.

When a stem cell divides, the new cells may either become another stem cell or a specific cell, such as a blood cell, a brain cell, or a muscle cell.

Scientists call a stem cell an undifferentiated cell because it can become any cell. In contrast, a blood cell, for example, is a ‘differentiated’ cell, because it is already a specific kind of cell.

 Source: Medical News Today

Friday 18 December 2020

What is hyperbaric oxygen therapy good for?

 Hyperbaric oxygen therapy (HBOT) involves breathing almost pure oxygen in a special room or small chamber.

Its main use is to treat diving-related illness, but it may enhance healing in people with various other conditions.

In 1662, a physician built the first hyperbaric chamber — a sealed room with a series of bellows and valves. The belief was that pressure could help treat certain respiratory diseases.

In the 1940s, HBOT became standard treatment for military divers in the United States.

However, while there are around 1,200 HBOT centers in the country, only two are mainly dedicated to treating diving injuries, according to the Divers Alert Network (DAN).

The Food and Drug Administration (FDA) have approved HBOT as a treatment for 13 conditions, but some people are calling for further approvals. Find out more about the benefits and risks of HBOT here.

 Source: Medical News Today

Thursday 17 December 2020

Are sardines good for you?

 Sardines are oily fish rich in omega-3 fatty acids. They are a good source of protein, vitamins, and minerals, and they may have less mercury contamination than larger fish.

Sardines are small, soft-boned fish that belong to the herring family. The name sardine may come from the Mediterranean island of Sardinia, where these fish were once abundant.

Sardines are available fresh, canned, smoked, or pickled.

In this article, we look at how to include sardines in the diet and the possible health benefits. We also explain what to consider when buying sardines and how many a person should eat.

Health benefits

Sardines are oily fish that contain omega-3 fatty acids, which are fats often present in plants and marine organisms. The fish are also a good source of protein, vitaminsselenium, and calcium.

Omega-3 fatty acids

Omega-3 fatty acids are essential components of cell membranes. A person must get these fatty acids from food because the human body cannot make them.

There are three main omega-3 fatty acids, two of which occur naturally in fish — including sardines — and other seafood. These are eicosapentaenoic acid (EPA), which fish get from the algae they eat, and docosahexaenoic acid (DHA), which is in many parts of the human body, including the eyes, brain, and heart.

According to the 2015–2020 Dietary Guidelines for Americans, consuming 8 ounces (oz) per week of a variety of seafood provides, on average, 250 milligrams (mg) per day of EPA and DHA.

The guidelines point out that consuming this amount during pregnancy and breastfeeding is associated with improved infant health outcomes. However, pregnant and breastfeeding people should choose seafood with lower mercury levels.

This intake of seafood also has a link with reduced cardiac deaths in people with and without preexisting heart disease.

According to the National Institutes of Health (NIH), omega-3s provide other possible benefits, although further research is necessary to establish the exact forms and dosages. The omega-3 fatty acids may be beneficial for preventing cancer and alleviating the effects of other conditions, including:

  • Alzheimer’s disease, dementia, and cognitive function
  • age-related macular degeneration
  • rheumatoid arthritis

The authors of a 2014 meta-analysis of studies in which participants took EPA and DHA supplements concluded that omega-3 fatty acids are effective in reducing symptoms of depression.

Learn more about the possible health benefits of omega-3 fatty acids here.

Protein and vitamins

The recommended daily allowance (RDA) of protein for adults is 46–56 grams (g) per day, depending on age and sex. Sardines are a good source of protein, with one cup of canned sardines in oil containing 36.7 g of this macronutrient.

Selenium is an important antioxidant that affects reproduction, thyroid function, and DNA production. An adult’s RDA is 55 micrograms (mcg) per day, and a 100-g portion of canned sardines in oil contains 52.7 mcg of this mineral.

Sardines are also an excellent source of vitamin B12. A 100-g serving of canned sardines in oil contains 8.94 mcg of vitamin B12, which is almost four times an adult’s RDA of 2.4 mcg per day. Vitamin B12 helps keep the blood and nervous system healthy.

Healthy bones

People need calcium for healthy bones, and a drained cup of canned sardines in oil contains 569 mg of calcium, which is more than half the 1,000 mg that experts recommend for adults aged 19–50 years.

Sardines also contain other nutrients that are essential for healthy bones, such as vitamin D, magnesium, and phosphorus.

Weight loss

According to a 2018 review, omega-3 fatty acids may aid weight loss by altering metabolic processes. Some of these processes include appetite suppression, inflammation, and gene expression.

The same review suggests that omega-3 may regulate leptin, a hormone that tells a person that they are full.

The researchers conclude that while studies have not yet shown omega-3 to have consistent benefits for weight loss, they have demonstrated improvements in metabolic profile among people with obesity.

Source: Medical News Today

 

Wednesday 16 December 2020

What causes unexplained bruising on the legs?

Usually, it is easy to pinpoint the cause of a bruise. Often, the culprit is an acute injury. Sometimes, however, bruising seems to occur for no apparent reason. If unexplained bruising appears a lot on the legs, it could be a symptom of an underlying health condition.

Bruising often occurs when blood vessels beneath the skin incur damage. Blood leaks out of the vessels and pools beneath the skin, which causes skin discoloration.

This article will look at the potential causes of unexplained bruising on the legs. It will also cover when to see a doctor.

Factors that affect leg bruising 

Some people bruise more easily than others. The following sections will look at some of the factors that may increase a person’s likelihood of bruising.

Age

As a person ages, they become more susceptible to bruising. Bruises may also take longer to heal in older adults.

Family history

According to one older study, people with close family members who bruise easily may also experience frequent bruising.

The Centers for Disease Control and Prevention (CDC) also note that some inherited bleeding disorders, such as von Willebrand’s disease, can make people more susceptible to bruising

Health conditions 

Most of the time, bruising occurs when a person bumps into things, falls, or injures themselves in another way. Bruises typically heal within a few weeks and are usually benign.

Sometimes, however, bruising is a symptom of a more significant health issue.

The following are a few of the possible conditions that may cause random bruising to appear on the legs.

Vitamin deficiencies

People who experience malnutrition could be deficient in vitamin C and may develop scurvy. Other people at risk of developing scurvy include older adults and people who drink a lot of alcohol.

Symptoms of scurvy include bleeding issues that may lead to bruising.

People deficient in vitamin K may also bruise more often. This is because their blood does not clot efficiently.

Although anyone can experience a vitamin K deficiency, it is more common in infants, as breast milk does not contain much of this nutrient.

Liver disease

A damaged liver affects the body’s ability to form clots and stop bleeding. According to the American Liver Foundation, people with cirrhosis may bleed or bruise more easily.

Other symptoms of cirrhosis include:

  • swelling of the legs and abdomen
  • yellowing of the skin, or jaundice
  • severe itching

Treatment

If a person receives a diagnosis of liver disease early enough, the odds of the liver healing itself are higher.

The treatment pathways for liver disease — and cirrhosis, in particular — aim to prevent further liver damage and protect the remaining healthy tissue.

Because alcohol abuse disorder is a common cause of liver disease, some treatments may involve alcohol rehabilitation to help the person stop drinking and prevent further liver damage.

Autoimmune conditions

Some autoimmune conditions, such as rheumatoid arthritis and lupus, may cause unexplained bruising.

Certain medications that help treat rheumatoid arthritis, including corticosteroids, may also contribute to random bruising.

Thrombocytopenia

Thrombocytopenia is a condition that involves low blood platelet counts. When there are not enough platelets, the blood does not clot properly, which could increase the risk of a serious bleed.

Complications from the following may give rise to thrombocytopenia:

  • medication use
  • surgery
  • pregnancy
  • heavy alcohol consumption
  • chemical exposure
  • viruses and infections
  • genetic disorders
  • autoimmune conditions
  • cancer

Approximately 5–10% of pregnant people and those who have recently given birth develop gestational thrombocytopenia.

Some cancer treatments, such as chemotherapy, could increase a person’s risk of bleeding and bruising. This is because these therapies reduce the amount of platelets in the blood.

Some other symptoms of a low platelet count include:

  • rashes consisting of small dots, which are broken blood vessels
  • recurrent heavy nosebleeds
  • heavy menstrual bleeding
  • fatigue

In severe cases, thrombocytopenia may cause internal bleeding and brain hemorrhage.

Treatment

There are several treatment options for thrombocytopenia. These include:

  • corticosteroids
  • immunoglobulins
  • blood or platelet transfusions
  • splenectomy

    Source: Medical News Today