This simple amino acid supplement greatly reduces Alzheimer’s damage

 Alzheimer's disease (AD) is a progressive brain disorder and a leading cause of dementia worldwide. Despite years of research, there is still no cure. New antibody-based treatments that target amyloid β (Aβ) have recently emerged, but their benefits have been modest. These therapies can also be expensive and may trigger immune-related side effects, underscoring the urgent need for safer, more affordable options that can slow the disease.

A recent study published in Neurochemistry International offers a surprising possibility. Researchers from Kindai University and partner institutions found that arginine, a naturally occurring amino acid, can reduce the buildup of harmful Aβ proteins in animal models of Alzheimer's. Arginine also acts as a safe chemical chaperone, helping proteins maintain their proper structure.

The team noted that while arginine is widely available as an over-the-counter supplement, the doses and methods used in this study were specifically designed for research and are not the same as commercial products.

The research group included Graduate Student Kanako Fujii and Professor Yoshitaka Nagai from the Department of Neurology at Kindai University Faculty of Medicine in Osaka, along with Associate Professor Toshihide Takeuchi from the Life Science Research Institute at Kindai University.

Lab and Animal Studies Show Strong Effects

In laboratory experiments, the scientists first showed that arginine can block the formation of Aβ42 aggregates, which are considered especially toxic. The effect increased with higher concentrations.

They then tested oral arginine in two well-established Alzheimer's models:

• A Drosophila model, expressing Aβ42 with the Arctic mutation (E22G)
• An AppNL-G-F knock-in mouse model, carrying three familial AD mutations

In both cases, arginine treatment reduced the accumulation of Aβ and lessened its harmful effects.

"Our study demonstrates that arginine can suppress Aβ aggregation both in vitro and in vivo," explains Prof. Nagai. "What makes this finding exciting is that arginine is already known to be clinically safe and inexpensive, making it a highly promising candidate for repositioning as a therapeutic option for AD."

Improved Brain Health and Reduced Inflammation

In the mouse model, the benefits went beyond reducing protein buildup. Arginine lowered amyloid plaque levels and reduced the amount of insoluble Aβ42 in the brain. Treated mice also performed better in behavioral tests.

The researchers found that arginine reduced the activity of genes linked to pro-inflammatory cytokines, which are associated with neuroinflammation, a major feature of Alzheimer's disease. This suggests that arginine may not only prevent harmful protein aggregation but also protect brain cells more broadly.

"Our findings open up new possibilities for developing arginine-based strategies for neurodegenerative diseases caused by protein misfolding and aggregation," notes Prof. Nagai. "Given its excellent safety profile and low cost, arginine could be rapidly translated to clinical trials for Alzheimer's and potentially other related disorders."

A Low-Cost Path Toward New Alzheimer's Treatments

The study highlights the growing interest in drug repositioning, which involves finding new uses for existing, well-established compounds. Because arginine is already used clinically in Japan and has been shown to safely reach the brain, it could bypass some of the early hurdles that slow down traditional drug development.

Still, the researchers caution that more work is needed. Additional preclinical and clinical studies will be required to determine whether these results can be reproduced in humans and to establish the most effective dosing strategies.

Even so, the findings provide strong early evidence that simple nutritional or pharmacological approaches may help reduce amyloid buildup and improve brain function.

Expanding Understanding of Alzheimer's Biology

Beyond its potential as a treatment, this work sheds new light on how Aβ proteins form and accumulate in the brain. It also points to a practical and cost-effective strategy that could eventually benefit millions of people living with Alzheimer's worldwide.

Professor Yoshitaka Nagai, a neurologist and Chair of the Department of Neurology at Kindai University Faculty of Medicine in Osaka, focuses his research on neurodegenerative diseases including Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis. His work centers on protein misfolding and RNA-related mechanisms, and he has received multiple honors from organizations such as the Japanese Society of Neurochemistry and the Japanese Dementia Society.

This research was supported by the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) (Grant No. 20H05927), Japan Society for the Promotion of Science (JSPS) (Grant Nos. 24H00630, 21H02840, 22H02792, and 25K02432), Japan Science and Technology Agency (JST) Super-Highway Program (SHW2023-03), and National Center of Neurology and Psychiatry.

Source: ScienceDaily

Scientists say travel could slow aging and boost your health

 Retinol creams may get most of the attention in the fight against visible aging, but researchers at Edith Cowan University (ECU) have pointed to a much bigger and more adventurous possibility: travel.

In a 2024 interdisciplinary study published in the Journal of Travel Research, ECU researchers applied the theory of entropy to tourism, proposing that positive travel experiences may support physical and mental health in ways that could help slow some signs of aging. The work does not suggest that travel can stop aging, but it frames tourism as more than a break from routine. It may be a way to help the body maintain balance, resilience, and repair.

How Travel Could Influence Aging

Entropy is often described as the universe's movement toward disorder. In the context of health, the researchers suggest that experiences can either support or disrupt the body's ability to stay organized and functioning well. Positive travel experiences may help reduce that drift toward disorder, while stressful or unsafe travel may push the body in the opposite direction.

"Aging, as a process, is irreversible. While it can't be stopped, it can be slowed down," ECU PhD candidate Ms. Fangli Hu said.

According to Ms. Hu, travel may improve well being by placing people in new environments, encouraging movement, increasing social interaction, and creating positive emotions. Those same ideas already appear in areas such as wellness tourism, health tourism, and yoga tourism.

"Tourism isn't just about leisure and recreation. It could also contribute to people's physical and mental health," Ms. Hu added.

Travel Therapy and the Body's Defense Systems

Viewed through an entropy lens, travel therapy could become a meaningful health intervention, Ms. Hu said. The idea is that positive travel experiences, as part of a person's environment, may help the body maintain a healthier low entropy state by influencing four major body systems.

Travel often combines unfamiliar surroundings with relaxing experiences. New settings can stimulate the body, raise metabolic activity, and help activate self organizing processes that keep biological systems working smoothly. These experiences may also prompt the adaptive immune system, which helps the body recognize and respond to outside threats.

Ms. Hu said that this reaction improves the body's ability to perceive and defend itself against external threats.

"Put simply, the self-defense system becomes more resilient. Hormones conducive to tissue repair and regeneration may be released and promote the self-healing system's functioning."

Stress Relief, Movement, and Healthy Aging

Relaxing travel activities may also help reduce chronic stress and calm an overactive immune response. Recreation can ease tension and fatigue in the muscles and joints, supporting metabolic balance and strengthening the body's ability to resist wear and tear.

This matters because travel is rarely just sitting still. Trips often include walking through cities, hiking trails, climbing, cycling, or simply spending more time on your feet than usual. That physical activity can increase metabolism, energy use, and nutrient movement throughout the body, all of which may support the systems that keep the body repaired and resilient.

"Participating in these activities could enhance the body's immune function and self-defense capabilities, bolstering its hardiness to external risks. Physical exercise may also improve blood circulation, expedite nutrient transport, and aid waste elimination to collectively maintain an active self-healing system. Moderate exercise is beneficial to the bones, muscles, and joints in addition to supporting the body's anti-wear-and-tear system," Ms. Hu said.

A Field That Is Still Taking Shape

Since the 2024 study, related work has continued to explore travel therapy as a possible health and wellness approach. A 2025 research note by Hu and colleagues described travel therapy as an emerging approach in which positive travel experiences may promote well being, while also emphasizing the need to weigh benefits against risks.

Another 2025 paper called for closer collaboration between travel medicine and tourism, reflecting a growing interest in how vacations, health risks, preventive care, and traveler well being overlap. A 2025 systematic review also found that tourism and healthy aging is becoming an important interdisciplinary research area, but remains underexplored and in need of stronger methods and clearer future research directions.

Source: ScienceDaily

Scientists just created exotic new forms of matter that shouldn’t exist

 Quantum technology is widely expected to transform how large and complex data sets are processed. Although it is currently used mostly in laboratories and research environments, the field is steadily moving toward real-world applications across a range of industries.

In a recent study exploring the fundamentals of quantum physics, researchers examined how matter behaves at extremely small scales, including atoms, electrons, and photons. The work, led by Cal Poly Physics Department Lecturer Ian Powell, focused on how varying a magnetic field over time can cause matter to exhibit unusual and previously unseen properties.

Powell and student researcher Louis Buchalter, who earned a Cal Poly bachelor's degree in physics in 2025, published their findings in Physical Review B in a paper titled "Flux-Switching Floquet Engineering." Their research shows that when magnetic fields are changed in a controlled, time-dependent way, they can generate quantum states that do not exist in materials that remain unchanged over time (remaining in the same state as time elapses).

"On a big-picture level, I would describe this as an advance in our understanding of how time-dependent control can create and organize new forms of quantum matter," Powell said. "The central idea is that useful quantum properties can depend not just on what a material is, but on how it is driven in time. In our case, we show that periodically changing a magnetic field can produce driven quantum phases with no static counterpart."

Toward More Stable Quantum Technologies

By carefully timing how magnetic fields are applied, scientists can design quantum systems with properties that are more stable and less vulnerable to "noise" or imperfections. These disruptions are a major challenge in quantum technology, often leading to errors in calculations or system performance.

Powell noted that while the technical details can be difficult to explain outside the field, the broader concept is clear. The findings suggest new ways to create and study these unusual quantum states in controlled settings such as ultracold-atom experiments.

"The most direct industry relevance of our study is to quantum computing and quantum simulation, rather than to a specific end-use sector at this stage," Powell said. "Any eventual impact on areas like pharmaceuticals, finance, manufacturing or aerospace would likely be indirect, by contributing to the longer-term development of better quantum technologies. To move toward industry use, the next steps would be experimental validation and further work connecting these ideas to realistic quantum-device platforms."

New Mathematical Patterns in Quantum Systems

Beyond creating new quantum states, the research also identified a mathematical organizing principle that mirrors patterns typically found in higher-dimensional quantum systems. This suggests that relatively simple systems driven by changing conditions could provide new ways to explore more complex quantum physics.

The team also mapped out how these exotic states form, revealing a precise structure in the system's topological phase diagram. This diagram serves as a visual guide to different stable quantum phases, each defined by fixed topological properties.

Why Quantum Control Matters for Computing

Quantum mechanics allows computing systems to process information in ways that far exceed the capabilities of classical computers. These systems can perform large-scale simulations, analyze vast data sets, and solve complex problems more efficiently.

Magnetic fields play a central role in this process. They are commonly used to control and measure quantum bits (or qubits), the fundamental units of quantum information. Qubits are comparable to the units of 0s and 1s in classicalcomputing (applied in commonplace computing currently) used to represent physical electrical states.

Student Research Experience and Future Work

For Buchalter, participating in the study provided valuable insight into the research process and scientific communication.

"A lot about the process of conducting research and how new research findings are effectively communicated with the broader scientific community."

"I learned that research is rarely a straightforward process, often requiring persistence and creative problem solving during the course of a research project," Buchalter said. "I believe our results help demonstrate the power of Floquet engineering for realizing quantum systems with highly-tunable properties, paving the way for further research into periodically driven quantum matter and the development of its applications."

Source: ScienceDaily

DNA research just rewrote the origin of human species

 A sweeping genetic analysis is challenging one of the simplest versions of the human origin story: the idea that all modern humans arose from a single ancestral population in Africa. Instead, the research points to a more intricate beginning, with early human groups spread across Africa, mixing for long stretches of time before some of their differences became visible in the DNA of people living today.

The study, published in Nature in 2023, compared genetic material from present day African populations with fossil evidence from early Homo sapiens populations. The result was a model of human evolution that replaces a clean family tree with something more like a network of deeply connected branches.

A More Complex Beginning in Africa

Scientists broadly agree that Homo sapiens originated in Africa. The harder question is how early human groups separated, moved, reconnected, and shaped one another across the continent.

Brenna Henn, professor of anthropology and the Genome Center at UC Davis and corresponding author of the study, said the uncertainty comes from gaps in both fossils and ancient DNA.

"This uncertainty is due to limited fossil and ancient genomic data, and to the fact that the fossil record does not always align with expectations from models built using modern DNA," she said. "This new research changes the origin of species."

The work was co led by Henn and Simon Gravel of McGill University. Their team tested several competing ideas about human evolution and migration in Africa, drawing from models proposed in paleoanthropology and genetics. The analysis included genome data from southern, eastern and western Africa.

The Nama Genomes Added a Key Clue

A major part of the study came from 44 newly sequenced genomes from modern Nama individuals in southern Africa. The Nama are an Indigenous population known for carrying unusually high levels of genetic diversity compared with many other living groups.

Researchers collected saliva samples from people in their villages between 2012 and 2015, while participants were going about daily life. Those samples helped the team examine whether human origins fit a single source model or something broader and more interconnected.

The best fitting model suggested that the earliest population split among early humans still detectable in living people happened roughly 120,000 to 135,000 years ago. Before that split, two or more weakly differentiated Homo populations had been exchanging genes for hundreds of thousands of years.

Even after the split, movement and mating continued between these early groups. The researchers describe this as a weakly structured stem, meaning the roots of modern humans were not one isolated population, but a loose set of connected populations with ongoing gene flow.

Not One Branch, But a Network

That network like model may explain human genetic diversity better than older models, according to the authors. Instead of needing to assume major contributions from an unknown archaic hominin population in Africa, the model shows how patterns in modern DNA could have emerged from structure within ancestral human populations themselves.

"We are presenting something that people had never even tested before," Henn said of the research. "This moves anthropological science significantly forward."

Co-author Tim Weaver, a UC Davis professor of anthropology who studies early human fossils, said the results shift how scientists should think about older explanations.

"Previous more complicated models proposed contributions from archaic hominins, but this model indicates otherwise," he said.

Weaver contributed comparative fossil expertise to the study, helping connect genetic models with what early human remains looked like.

What This Means for Ancient Fossils

The model also has consequences for how scientists interpret the fossil record. According to the authors, only 1 to 4% of genetic differentiation among living human populations can be traced to variation between these ancestral stem populations.

Because the early branches continued mixing, they were probably similar in appearance. That means fossils with very different physical traits (such as Homo naledi) are unlikely to represent lineages that directly contributed to the evolution of Homo sapiens, the authors said.

In other words, the roots of humanity may have been geographically and genetically widespread, but not necessarily divided into sharply different human forms. The deeper picture is one of movement, contact, and repeated mixing across Africa.

Later Research Adds More Depth

Work published after the 2023 study has continued to show how important African genomic diversity is for understanding human origins. A 2024 Nature Ecology & Evolution study reported 9,000 years of genetic continuity in southernmost Africa, highlighting the region's long and unusually deep human population history.

A later Nature study analyzed genomes from 28 ancient southern African individuals dated between 10,200 and 150 years before present. That work found that ancient southern Africans carried genetic variation outside the range seen in living people and identified Homo sapiens specific variants that may shed light on adaptation and evolution within Africa.

Together, these findings strengthen a bigger message: human origins were not a single spark in one place. They were shaped by many populations, deep African diversity, and long periods of connection across the continent.

Additional co-authors of the 2023 study include Aaron Ragsdale, University of Wisconsin, Madison; Elizabeth Atkinson, Baylor College of Medicine; and Eileen Hoal and Marlo Möller, Stellenbosch University, South Africa.

Source: ScienceDaily

Blood vessels found in T. rex bones are rewriting dinosaur science

 Despite decades of effort, scientists have never recovered dinosaur DNA. Most paleontology research today still focuses on searching for traces of original organic material in fossils, but DNA has not survived the passage of time.

Much of what we understand about dinosaurs comes from fossilized bones and teeth. These durable remains preserve well, but they offer only limited insight into how these animals actually lived.

Soft tissues, on the other hand, can reveal far more. These rare fossilized materials include muscles and ligaments, pigments or even skin (like scales or feathers). They provide important clues about appearance, movement, and behavior.

Another type of soft tissue sometimes preserved inside bones is blood vessels. My research team and I identified preserved blood vessels in a Tyrannosaurus rex fossil, and our findings were recently published in Scientific Reports.

A Discovery That Began With Physics

As an undergraduate physics student at the University of Regina, I joined a research group that used particle accelerators to study fossils. During that time, I used advanced 3D imaging techniques to examine a T. rex bone and noticed structures that appeared to be blood vessels.

Nearly six years later, I am now pursuing a PhD, continuing to apply physics-based methods to improve how fossils are analyzed.

The Largest T. Rex Ever Found

The preserved vessels came from an extraordinary specimen known as Scotty. Housed at the Royal Saskatchewan Museum in Canada, Scotty is the largest T. rex ever discovered and one of the most complete.

Evidence suggests Scotty lived a difficult life around 66 million years ago. Many of its bones show signs of injury, possibly from combat with another dinosaur or from disease. One rib stands out, showing a large fracture that had only partially healed.

When bones are damaged, the body increases blood vessel activity in the affected area to support healing. The structures we observed in Scotty's rib appear to be part of that process, forming a dense network of mineralized vessels that we reconstructed using 3D models.

Advanced Imaging Reveals Hidden Structures

Studying the inside of fossil bones presents two major challenges. First, researchers need to look inside without damaging the specimen. Second, fossilized bones are extremely dense because minerals have replaced the original organic material over millions of years.

We initially considered using an computed topography (CT) scan, similar to those used in medicine. While this method is non-destructive, standard CT scanners cannot penetrate the dense structure of large fossils.

Instead, we turned to synchrotron light, a powerful form of high-intensity x-rays produced at specialized particle accelerator facilities. This technique allowed us to visualize tiny internal features such as blood vessels with remarkable clarity.

Synchrotron imaging also made it possible to analyze the chemical composition of the structures. The vessels had been preserved as iron-rich mineralized casts, which is a common fossilization process. Interestingly, they appeared in two distinct layers, reflecting a complex environmental history that contributed to their preservation.

What Blood Vessels Reveal About Dinosaur Life

The partially healed fracture in Scotty's rib offers a rare opportunity to study how a T. rex recovered from injury. By examining the preserved blood vessels, researchers can gain insight into healing processes and survival strategies in large predatory dinosaurs.

This work may also provide a basis for comparison with other dinosaur species and with modern animals such as birds, which are closely related to dinosaurs.

The findings could guide future fossil discoveries as well. Bones that show signs of injury or disease may be more likely to preserve blood vessels or other soft tissues, helping scientists target promising specimens.

With the combination of physics, paleontology, and advanced imaging technologies, researchers are beginning to uncover details about dinosaur biology that were once thought impossible to study.

Source: ScienceDaily

Panama’s ocean lifeline vanishes for the first time in 40 years

Each year during Central America's dry season (generally between December and April), strong northern trade winds help drive an important ocean process in the Gulf of Panama. These winds push surface waters in a way that allows colder, nutrient-rich water from deep below to rise toward the surface.

This process, known as upwelling, plays a major role in the region's marine life. It fuels highly productive fisheries, helps shield coral reefs from heat stress, and keeps the water along Panama's Pacific beaches cooler during the busy "summer" vacation season.

A 40-Year Pattern Suddenly Changed

Scientists at the Smithsonian Tropical Research Institute (STRI) have tracked this seasonal upwelling for decades. Their records show that from January to April, the event has been a reliable and predictable part of the Gulf of Panama for at least 40 years.

But in 2025, researchers documented something they had never seen before. For the first time in their records, this essential oceanographic process did not occur. The usual seasonal cooling was weakened, and the expected surge in ocean productivity was also reduced.

Weaker Winds May Be the Cause

In a recently published article in the journal PNAS, the scientists suggest that a major drop in wind patterns likely drove the unprecedented failure. The finding shows how quickly climate disruption can interfere with basic ocean processes that have supported coastal fishing communities for thousands of years.

Researchers caution that more work is still needed to identify the exact cause and understand what the event could mean for fisheries.

Tropical Oceans Need Better Monitoring

The discovery points to the rising vulnerability of tropical upwelling systems. These systems are enormously important for ecosystems and coastal economies, yet they remain poorly monitored in many parts of the world.

The findings also highlight the need to improve ocean climate observation and forecasting across tropical regions.

The result is one of the first major outcomes from the collaboration between the S/Y Eugen Seibold research vessel from the Max Planck Institute and STRI.

Source: ScienceDaily

Mezcal worm in a bottle DNA test reveals a surprise

 At the bottom of some mezcal bottles sits one of the most recognizable curiosities in the world of spirits: a pale, curled "worm" preserved in alcohol. It has helped give mezcal an air of mystery for decades, but scientists have now shown that this famous bottle stowaway is not a worm at all.

Mezcal is a distilled drink made from agave, the same plant group used to produce tequila. Most bottles are sold without anything added, but a small number contain larvae known as gusanos de maguey (Spanish for agave worms). The tradition feels ancient, but it is actually much more recent than mezcal itself. While mezcal production reaches back centuries in Mexico, the practice of placing larvae in bottles appears to have begun in the 1940s.

A Longstanding Mezcal Mystery

For years, the true identity of these larvae remained uncertain. They had been described as moth larvae, butterfly larvae, and even weevil larvae. Some people suspected more than one species might be involved, especially because the bottled "worms" can vary in color and appearance.

"It's relatively easy to broadly determine the kind of larva based on the shape of the head, but their identity has never been confirmed," said Akito Kawahara, curator at the Florida Museum's McGuire Center for Lepidoptera and Biodiversity. "This is probably because most biologists are not looking inside mezcal bottles."

To settle the question, Kawahara and his colleagues studied mezcal gusanos in research published in 2023 in PeerJ Life & Environment. In 2022, the team traveled to Oaxaca, Mexico, a region deeply tied to mezcal production. They visited distilleries and gathered as many different brands as they could find so they could sample larvae from a variety of bottles.

The larvae did not offer many obvious clues. After sitting in alcohol, their bodies were preserved, but many visible traits that might help identify them were limited. That preservation, however, also protected something far more useful: DNA.

DNA Revealed a Surprising Answer

The researchers were able to extract and analyze genetic material from 18 specimens. They expected the results might point to several different insects, since gusanos de maguey are harvested from the wild rather than raised through a standardized commercial system.

One leading suspect was the tequila giant skipper (Aegiale hesperiaris), a butterfly whose caterpillars feed on agave plants. Its large, whitish larvae seemed like a strong match for many of the pale gusanos seen in mezcal bottles. Its name also made it an obvious candidate.

But the DNA told a different story. Every larva that produced usable genetic data matched the agave redworm moth (Comadia redtenbacheri). In the PeerJ study, specimens that did not produce usable DNA were also identified morphologically as the same species.

Source: ScienceDaily

This new brain-like chip could slash AI energy use by 70%

 Scientists have created a new type of nanoelectronic device that could significantly reduce how much energy artificial intelligence systems consume. The innovation works by copying how the human brain processes information, offering a more efficient alternative to today's power-hungry AI hardware.

The research team, led by the University of Cambridge, developed a modified version of hafnium oxide that functions as a highly stable, low-energy 'memristor' -- a component designed to replicate how neurons connect and communicate in the brain. Their findings were published in the journal Science Advances.

Why Current AI Systems Use So Much Energy

Modern AI relies on traditional computer chips that constantly move data between memory and processing units. This back-and-forth transfer requires large amounts of electricity, and demand continues to rise as AI becomes more widely used across industries.

Neuromorphic computing offers a different approach. Instead of separating memory and processing, it combines both in one place, similar to how the brain works. This method could cut energy use by as much as 70% while also allowing systems to learn and adapt more naturally.

"Energy consumption is one of the key challenges in current AI hardware," said lead author Dr. Babak Bakhit, from Cambridge's Department of Materials Science and Metallurgy. "To address that, you need devices with extremely low currents, excellent stability, outstanding uniformity across switching cycles and devices, and the ability to switch between many distinct states."

A New Approach to Memristor Design

Most existing memristors operate by forming tiny conductive filaments inside metal oxide materials. These filaments tend to behave unpredictably and often require high voltages, which limits their practicality for large-scale computing.

The Cambridge researchers took a different route. They engineered a hafnium-based thin film that switches states through a more controlled mechanism. By adding strontium and titanium and using a two-step growth process, they created small electronic gates, known as 'p-n junctions', at the interfaces between layers.

Instead of relying on filaments forming and breaking, the device changes its resistance by adjusting the energy barrier at these interfaces. This allows for smoother and more reliable switching.

Bakhit, who is also affiliated with Cambridge's Department of Engineeirng, explained that this design solves a major issue in memristor development. "Filamentary devices suffer from random behavior," he said. "But because our devices switch at the interface, they show outstanding uniformity from cycle to cycle and from device to device."

Source: ScienceDaily

Simple “gut reset” may stop weight gain after Ozempic or Wegovy

 A minimally invasive outpatient procedure may help people avoid regaining weight after stopping popular medications like Ozempic and semaglutide, according to research being presented at Digestive Disease Week® (DDW) 2026. About 70% of people who stop these drugs eventually regain much of the weight they lost, often within 18 months. Nearly one in five adults with obesity has used a glucagon-like peptide-1 (GLP-1), highlighting the scale of this challenge.

Researchers report the first blinded, randomized, sham-controlled evidence that a procedure called duodenal mucosal resurfacing may offer a safe and lasting way to maintain weight loss without ongoing medication. The findings suggest it could help patients hold onto the benefits they achieved while taking drugs such as Ozempic or other GLP-1 therapies.

"As effective as GLP-1 medications are, many people stop taking them because of cost, side effects or simply not wanting to take a drug long-term," said lead author Shelby Sullivan, MD, director of the Endoscopic Bariatric and Metabolic Program at Dartmouth Health Weight Center and professor of medicine, Dartmouth Geisel School of Medicine. "But, if they stop these medications, weight regain occurs in the vast majority of patients, and the metabolic benefits are lost. Finding a treatment that allows patients to stop these medications without weight regain or loss of metabolic benefit is a huge unmet need. These findings indicate that this minimally invasive procedure may provide lasting weight-loss maintenance."

How the "Gut Reset" Procedure Works

Duodenal mucosal resurfacing is an investigational endoscopic treatment that uses controlled heat to remove damaged tissue from the inner lining of the duodenum, the first section of the small intestine just below the stomach. This process, which ablates (burns) the unhealthy mucosal layer, encourages the growth of new, healthier tissue.

The ongoing REMAIN-1 trial is designed to test whether this renewal of the intestinal lining can trigger a lasting metabolic reset, helping the body maintain weight loss after stopping medications like semaglutide or tirzepatide.

Trial Results Show Less Weight Regain

The current findings come from an early group of participants with six months of follow-up data. Among 45 people in this cohort, 29 received the resurfacing treatment while 16 underwent a sham procedure. All participants had previously lost at least 15% of their body weight using tirzepatide before stopping the drug.

On average, patients lost about 40 pounds while on GLP-1 therapy. Six months after discontinuing the medication, those in the control group regained significantly more weight. Participants who received the sham procedure regained about 40% more weight than those who underwent the actual treatment.

In addition, patients who had more extensive resurfacing regained only about 7 pounds and kept more than 80% of their weight loss. By comparison, the control group regained roughly twice as much. The gap between the two groups continued to widen from one to six months after the procedure, suggesting the benefits may persist and even strengthen over time.

"What's particularly encouraging is that the benefit appears to increase over time rather than fade, and that it behaves like a drug in terms of dose response," Dr. Sullivan said. "That gives us confidence that we're targeting the right biology."

Safety and Recovery

No serious complications were reported from either the device or the procedure. Recovery is relatively quick, with most patients returning to normal activities within about a day.

"Other than recovering from the general anesthesia, there isn't much recovery time involved," Dr. Sullivan said. "You can be back to your daily routine in about a day. Participants could not tell if they had the sham or real procedure because there are not a lot of symptoms after the procedure."

Why the Gut Is Key to Weight Regulation

The treatment targets the small intestine, where many of the hormones affected by GLP-1 drugs are produced. Over time, diets high in fat and sugar can alter the lining of the duodenum, changing how the body processes food and regulates hormones. These changes can contribute to insulin resistance and metabolic disease.

By restoring a healthier mucosal layer, the procedure aims to reset how the body responds to food, helping stabilize metabolism at a lower body weight after stopping medications like Ozempic.

Source: ScienceDaily

For the first time, scientists pinpoint the brain cells behind depression

 Researchers at McGill University and the Douglas Institute have discovered that two distinct types of brain cells function differently in people with depression.

The findings, published in Nature Genetics, offer important clues that could lead to new treatments designed to target these specific cells. They also provide a clearer understanding of depression, a condition that affects more than 264 million people worldwide and remains a leading cause of disability.

"This is the first time we've been able to identify what specific brain cell types are affected in depression by mapping gene activity together with mechanisms that regulate the DNA code," said senior author Dr. Gustavo Turecki, a professor at McGill, clinician-scientist at the Douglas Institute and Canada Research Chair in Major Depressive Disorder and Suicide. "It gives us a much clearer picture of where disruptions are happening, and which cells are involved."

Rare Brain Tissue Enables Breakthrough

To make this discovery, the research team relied on post-mortem brain samples from the Douglas-Bell Canada Brain Bank. This collection is one of the few in the world that includes donated brain tissue from individuals who had psychiatric conditions, making it an invaluable resource for studying mental health at a biological level.

Using advanced single-cell genomic techniques, the scientists examined RNA and DNA from thousands of individual brain cells. This approach allowed them to pinpoint which cells behaved differently in people with depression and to identify genetic patterns that might explain those differences. The study included samples from 59 individuals diagnosed with depression and 41 without the condition.

Key Brain Cells Show Altered Activity

The analysis revealed changes in gene activity in two important types of brain cells. One was a group of excitatory neurons that play a role in regulating mood and responding to stress. The other was a subtype of microglia, immune cells in the brain that help control inflammation.

In both cell types, many genes showed different levels of activity in people with depression, suggesting that these systems may not be functioning normally. These disruptions could help explain how depression develops at a biological level.

Rethinking Depression as a Brain Disorder

By identifying the specific cells involved, the study strengthens the case that depression has a clear biological foundation. It also challenges outdated views that treat the condition as purely emotional or psychological.

"This research reinforces what neuroscience has been telling us for years," Turecki said. "Depression isn't just emotional, it reflects real, measurable changes in the brain."

What Comes Next for Depression Research

The researchers now plan to investigate how these cellular differences affect overall brain function. They also hope to determine whether therapies that target these cells could lead to more effective treatments in the future.

About the Study

The paper, titled "Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression" by Anjali Chawla and Gustavo Turecki et al., was published in Nature Genetics.

Funding for the research was provided by the Canadian Institutes of Health Research, Brain Canada Foundation, Fonds de recherche du Québec -- Santé and the Healthy Brains, Healthy Lives initiative at McGill University.

Source: ScienceDaily

Think AI "knows" what it’s doing? Scientists say think again

 Think, know, understand, remember.

These are everyday words people use to describe what goes on in the human mind. But when those same terms are applied to artificial intelligence, they can unintentionally make machines seem more human than they really are.

"We use mental verbs all the time in our daily lives, so it makes sense that we might also use them when we talk about machines -- it helps us relate to them," said Jo Mackiewicz, professor of English at Iowa State. "But at the same time, when we apply mental verbs to machines, there's also a risk of blurring the line between what humans and AI can do."

Mackiewicz and Jeanine Aune, a teaching professor of English and director of the advanced communication program at Iowa State, are part of a research team that studied how writers describe AI using human-like language. This type of wording, known as anthropomorphism, assigns human traits to non-human systems. Their study, "Anthropomorphizing Artificial Intelligence: A Corpus Study of Mental Verbs Used with AI and ChatGPT," was published in Technical Communication Quarterly.

The research team also included Matthew J. Baker, associate professor of linguistics at Brigham Young University, and Jordan Smith, assistant professor of English at the University of Northern Colorado. Both previously studied at Iowa State University.

Why Human-Like Language About AI Can Be Misleading

According to the researchers, using mental verbs to describe AI can create a false impression. Words such as "think," "know," "understand," and "want" suggest that a system has thoughts, intentions, or awareness. In reality, AI does not possess beliefs or feelings. It produces responses by analyzing patterns in data, not by forming ideas or making conscious decisions.

Mackiewicz and Aune also pointed out that this kind of language can overstate what AI is capable of. Phrases like "AI decided" or "ChatGPT knows" can make systems seem more independent or intelligent than they actually are. This can lead to unrealistic expectations about how reliable or capable AI is.

There is also a broader concern. When AI is described as if it has intentions, it can distract from the humans behind it. Developers, engineers, and organizations are responsible for how these systems are built and used.

"Certain anthropomorphic phrases may even stick in readers' minds and can potentially shape public perception of AI in unhelpful ways," Aune said.

How News Writers Actually Use AI Language

To better understand how often this kind of language appears, the researchers analyzed the News on the Web (NOW) corpus. This massive dataset contains more than 20 billion words from English-language news articles published in 20 countries.

They focused on how frequently mental verbs such as "learns," "means," and "knows" were used alongside terms like AI and ChatGPT.

The findings were unexpected.

Mental Verbs Are Less Common Than Expected

The study found that news writers do not frequently pair AI-related terms with mental verbs.

While anthropomorphism is common in everyday speech, it appears far less often in news writing. "Anthropomorphism has been shown to be common in everyday speech, but we found there's far less usage in news writing," Mackiewicz said.

Among the examples identified, the word "needs" appeared most often with AI, showing up 661 times. For ChatGPT, "knows" was the most frequent pairing, but it appeared only 32 times.

The researchers noted that editorial standards may play a role. Associated Press guidelines, which discourage attributing human emotions or traits to AI, could be influencing how journalists write about these technologies.

Context Matters More Than the Words Themselves

Even when mental verbs were used, they were not always anthropomorphic.

For instance, the word "needs" often described basic requirements rather than human-like qualities. Phrases such as "AI needs large amounts of data" or "AI needs some human assistance" are similar to how people describe non-human systems like cars or recipes. In these cases, the language does not imply that AI has thoughts or desires.

In other cases, "needs" was used to express what should be done, such as "AI needs to be trained" or "AI needs to be implemented." Aune explained that these examples were often written in passive voice, which shifts responsibility back to human actors rather than the technology itself.

Anthropomorphism Exists on a Spectrum

The study also showed that not all uses of mental verbs are equal. Some phrases move closer to suggesting human-like qualities.

For example, statements like "AI needs to understand the real world" can imply expectations tied to human reasoning, ethics, or awareness. These uses go beyond simple descriptions and begin to suggest deeper capabilities.

"These instances showed that anthropomorphizing isn't all-or-nothing and instead exists on a spectrum," Aune said

Why Language Choices About AI Matter

Overall, the researchers found that anthropomorphism in news coverage is both less frequent and more nuanced than many might assume.

"Overall, our analysis shows that anthropomorphization of AI in news writing is far less common -- and far more nuanced -- than we might think," Mackiewicz said. "Even the instances that did anthropomorphize AI varied widely in strength."

The findings highlight the importance of context. Simply counting words is not enough to understand how language shapes meaning.

"For writers, this nuance matters: the language we choose shapes how readers understand AI systems, their capabilities and the humans responsible for them," Mackiewicz said.

The research team also emphasized that these insights can help professionals think more carefully about how they describe AI in their work.

"Our findings can help technical and professional communication practitioners reflect on how they think about AI technologies as tools in their writing process and how they write about AI," the research team wrote in the published study.

As AI continues to develop, the way people talk about it will remain important. Mackiewicz and Aune said writers will need to stay mindful of how word choices influence perception.

Looking ahead, the team suggested that future studies could explore how different words shape understanding and whether even rare uses of anthropomorphic language have a strong impact on how people view AI.

Source: ScienceDaily

Scientists say this type of olive oil could boost brain power

 Extra virgin olive oil has long been a cornerstone of the Mediterranean diet, known for supporting heart and metabolic health. Now, new research suggests it may also help protect the brain. Scientists have found that its benefits could extend beyond the body to the mind, working through the gut microbiome to support cognitive function.

A study led by researchers from the Human Nutrition Unit at the Universitat Rovira i Virgili (URV), the Pere Virgili Health Research Institute (IISPV) and CIBERobn points to a meaningful link between extra virgin olive oil, gut bacteria, and brain health.

Study explores olive oil, gut microbiome, and brain health

"This is the first prospective study in humans to specifically analyze the role of olive oil in the interaction between gut microbiota and cognitive function," explains Jiaqi Ni, first author of the article and researcher at the URV's Department of Biochemistry and Biotechnology.

The research followed 656 adults between the ages of 55 and 75 who were overweight or obese and had metabolic syndrome -- a set of risk factors that increase the likelihood of developing cardiovascular disease. Over a two-year period, as part of the PREDIMED-Plus project, scientists tracked participants' diets, including their intake of virgin and refined olive oil, along with detailed analyses of their gut microbiota. They also monitored changes in cognitive performance over time.

Virgin olive oil linked to better cognition and gut diversity

The findings showed clear differences depending on the type of olive oil consumed. Participants who regularly used virgin olive oil experienced improvements in cognitive function and had a more diverse gut microbiota, which is widely considered a sign of better intestinal and metabolic health. In contrast, those who consumed refined olive oil tended to show a decline in microbiota diversity over time.

Researchers also identified a specific group of gut bacteria, known as Adlercreutzia, that may be tied to these benefits. Its presence could serve as an indicator of the positive relationship between virgin olive oil consumption and preserved cognitive function. These results suggest that part of the oil's brain-supporting effect may come from how it reshapes the gut microbiome.

Why extra virgin olive oil stands out

The difference between extra virgin and refined olive oil largely comes down to how they are produced. Extra virgin olive oil is obtained using mechanical methods, which help preserve its natural compounds. Refined olive oil, on the other hand, undergoes industrial processing to remove impurities.

While this refining process improves shelf life and taste consistency, it also reduces beneficial components such as antioxidants, polyphenols, vitamins and other bioactive substances. According to Jiaqi Ni, "not all olive oils have benefits for cognitive function," highlighting the importance of choosing extra virgin varieties.

Quality of dietary fats matters for brain health

These findings add to growing evidence that diet plays a key role in both cardiovascular and cognitive health through its influence on the gut microbiota. Jordi Salas-Salvadó, principal investigator of the study, emphasizes the importance of choosing high-quality fats: "This research reinforces the idea that the quality of the fat we consume is as important as the quantity; extra virgin olive oil not only protects the heart, but can also help preserve the brain during aging."

He also notes that identifying a specific microbial profile linked to these benefits "paves the way for new nutrition-based prevention strategies to preserve cognitive functions."

A simple dietary change for an aging population

Co-directors Nancy Babio and Stephanie Nishi highlight the broader implications of the findings as populations continue to age. "At a time when cases of cognitive decline and dementia are on the rise, our findings drive home the importance of improving diet quality, and in particular prioritizing extra virgin olive oil over other refined versions as an effective, simple and accessible strategy for protecting brain health."

The study was led by the Human Nutrition Unit at the URV's Department of Biochemistry and Biotechnology, with contributions from the Pere Virgili Health Research Institute (IISPV-CERCA) and the CIBER area on the Physiopathology of Obesity and Nutrition (CIBEROBN) of the Carlos III Health Institute. Researchers from the PREDIMED-Plus consortium also participated, along with collaborators from international institutions including Wageningen (Netherlands) and Harvard (United States).

Source: ScienceDaily