Monday, 31 May 2021

Medical myths: All about allergies

 For Asthma and Allergy Awareness Month, this edition of the Medical Myths series tackles some of the many myths and misconceptions associated with allergies.

In brief, an allergy is an unusual or exaggerated immune response triggered by a particular substance. Symptoms often include itchy eyes, wheezing, and sneezing. For many people, allergic reactions are uncomfortable and unpleasant, but they can be life threatening for others.

According to estimates from the Centers for Disease Control and Prevention (CDC), up to 60 millionTrusted Source people in the United States experience allergies each year.

The World Health Organization (WHO) estimates that around 20% of people worldwide have an allergic condition.

One of the most common allergies — hay fever — affected an estimated 19.2 millionTrusted Source adults in the U.S. during 2018, and this figure is likely to rise.

“Allergies are currently on the rise in the U.S.,” explained Dr. Omid Mehdizadeh, an otolaryngologist and laryngologist at Providence Saint John’s Health Center in Santa Monica, CA.

He told Medical News Today that “scientists believe the increasing prevalence of environmental allergies is due to changing weather patterns and increasing pollen blooms in the U.S.”

Considering their prevalence, understanding and dismissing the myths associated with allergies is an important task. Here, we tackle 11 such myths.

One persistent myth is that once you reach adulthood, you don’t develop any more allergies. This is untrue.

One studyTrusted Source, for instance, looked at the prevalence of food allergies in 40,443 adults in the U.S. At the time of the survey, 10.8% of participants had a food allergy.

The authors found that in around half of these individuals with food allergies, at least one of these food allergies developed during adulthood.

In general, the best way to minimize allergic reactions is to avoid triggers, whether a particular food or a type of animal. There are no cures for allergies.

However, certain treatments can effectively reduce the symptoms. For instance, decongestants can relieve the nasal symptoms of allergies, while antihistamines and nasal steroid sprays can also be effective.

Additionally, allergy immunotherapy can help reduce allergies. The American College of Allergy, Asthma, and Immunology states:

“Immunotherapy involves giving gradually increasing doses of the substance, or allergen, to which the person is allergic. The incremental increases of the allergen cause the immune system to become less sensitive to the substance, probably by causing production of a ‘blocking’ antibody, which reduces the symptoms of allergy when the substance is encountered in the future.”

This is not true: food allergies and food intolerances are different. When someone experiences a food allergy, it is driven by their immune systemTrusted Source, usually associated with the action of Immunoglobulin E (IgE).

During an IgE-mediated immune responseTrusted Source, IgE binds to receptors on specific cells, including mast cells and basophils. These cells then produce histamine and other compounds, causing symptoms to appear very rapidly.

On the other hand, intolerances do not involve the immune system, and symptoms take longer to appear. And while intolerances are not life threatening, food allergies can be in some cases.

Thankfully, this is a myth. Although some allergies do persist for life, as Dr. Mehdizadeh told MNT, “Some allergies may simply dissipate with age.”

Whether an allergy diminishes over time can depend on the allergen. The authors of a review on food allergies explain:

Although peanut allergies are common — affecting an estimated 6.1 million people in the U.S. — and can certainly be dangerous, there is no way to rank allergy severity. Some individuals might have only a mild reaction to peanuts but, for others, it could spark anaphylaxis.

Although certain foods, such as tree nuts, shellfish, and eggs, account for most allergies, virtually any food can trigger a reaction. The severity of the reaction depends on an individual’s immune system.

Source: Medical News Today

Sunday, 30 May 2021

MSG: What the science says about its safety

 Monosodium glutamate (MSG) continues to be a controversial food additive used around the world. In this Honest Nutrition feature, we explain the benefits and risks of MSG and dispel popular myths.

MSG, also known as the fifth taste or umamiTrusted Source, is the sodium salt of glutamate — an amino acid naturally occurring in many foods and food additivesTrusted Source and an important building block of protein in the body.

GlutamateTrusted Source was discovered from kombu seaweed in 1908 by Japanese professor of physical chemistry, Prof. Kikunae Ikeda. He later extracted the amino acid, dissolved it in water, and neutralized it with sodium hydroxide to form MSG.

Glutamate itself is bitter, but MSG has a unique flavor that led Ikeda to coin the term umamiTrusted Source, expanding upon four basic tastesTrusted Source: sweet, salty, bitter, and sour.

MSG occurs naturallyTrusted Source in various foods, such as carrot, onion, cabbage, potato, egg yolk, cheese, soy sauce, anchovies, and shrimp.

It is also produced through the fermentationTrusted Source of animal-based or plant-based foods, including molasses, sugarcane, sugar beet, beans, mushrooms, and seaweed.

MSG is used as a food additive and flavor enhancer either in the form of pure monosodium saltTrusted Source or from hydrolyzed protein products, such as vegetable protein.

It was widely accepted and used in Asian countries since its discovery but has been received with less skepticismTrusted Source in Western countries only in the second half of the 20th century.

It is commonly added to restaurant foods to enhanceTrusted Source their palatability. More recently, it has supplemented processed foods, such as frozen meals, canned tuna, dietary supplements, salad dressing, and infant formula.

In agriculture, it is used in combination with other ingredients and sold as AuxiGro, which is a fertilizer, pesticide, and plant primer whose role is to increase crop yield.

Myth: MSG is high in salt, or sodium

Fact: Sodium is an important nutrient the body needs in small amounts to maintain blood volume and blood pressure. However, expertsTrusted Source associate excess intake of sodium with high blood pressure and an increased risk of heart disease.

Unlike regular table salt, which is 40% sodium, MSG contains only 12% sodium, which is one-third the amount in table salt. ResearchersTrusted Source have also explored MSG as a viable alternative to salt to reduce sodium intake and improve public health through a reduced risk of hypertension.

Source: Medical News Today

Saturday, 29 May 2021

What to know about adult acne

 People may associate acne with the teenage years, but it can also occur in adulthood. Hormonal changes, stress, and certain medications can all contribute to adult acne. However, there are many options available to help individuals treat and prevent this skin condition.

Adult acne definition

Acne is a common inflammatory skin condition that affects roughly 50 million Americans annually. It usually begins in puberty but can occur at any stage in life and may continue into adulthood. Doctors may also refer to adult acne as adult-onset acne or postadolescent acne.

It typically develops when oil and dead skin cells plug pores on the skin, resulting in the development of lesions commonly referred to as zits or pimples.

Many different types of acne can occur all over the body. Acne most often develops on the face, but it can also present on the back, chest, and shoulders.

While acne is more common during adolescence, it is possible for acne to continue into a person’s 30s, 40s, and 50s. Some people may even develop acne for the first time as an adult. Research also notes that adult acne is more common in females.

The American Academy of Dermatology says that the most common causes of adult acne include the below.

Changes in hormones

Similar to the leading cause of acne in teenagers, a hormonal imbalance can result in acne. Many factors can alter hormone levels, including:

  • periods
  • pregnancy
  • perimenopause, which refers to the time leading up to and directly after menopause
  • menopause
  • starting or stopping birth control pills or other hormonal contraception

Stress

When experiencing stress, some people may have an acne flare-up, which is possibly due to the body producing more androgen hormones in response. These hormones can stimulate the oil glands in the skin, resulting in acne.

Family history

Some evidence suggests that some people may have a genetic predisposition for acne. This means that if a close blood relative, such as a parent or sibling, has acne, then a person may be more likely to develop adult acne.

Beauty products

Some hair and skin care products may contain substances that can aggravate acne-prone skin. Using them can result in acne breakouts. Therefore, people may wish to consider only using products labeled as:

  • noncomedogenic
  • non-acnegenic
  • oil free
  • will not clog pores

Medication side effects

Some medications can cause acne as a side effect. If a person suspects their medication is triggering their acne, they should continue taking the medicine but consider discussing alternative treatment options with their doctor.

Medications that may cause acne can include hormonal medicines, antidepressants, B vitamins, halogens, and antiepileptics.

Undiagnosed medical conditions

In some cases, adult acne may result from an underlying medical condition, so treating the condition can often cause acne to clear. For example, people with polycystic ovary syndrome typically develop adult acne due to fluctuations in their hormone levels.

Source: Medical News Today

Friday, 28 May 2021

What to know about radiation dermatitis

 Radiation dermatitis is one of the side effects of cancer treatment radiotherapy that people experience most often.

Also known as radiodermatitis, it happens when radiation therapy damages the outer layers of a person’s skin.

An estimated 95 percentTrusted Source of people who receive radiation therapy will have some form of radiation dermatitis, including redness, skin dryness, or skin peeling.

This article will explore radiation dermatitis, including what causes it, and how people can ease the symptoms at home.

Symptoms of radiation dermatitis include:

  • skin redness or pinkness, known as erythema
  • skin swelling, or edema
  • dry, peeling skin, called dry desquamation
  • skin that thins and weakens called moist desquamation
  • blisters or skin ulcers

The severity of radiation dermatitis varies between people and radiation doses in the following grades:

  • Grade 1, faint redness and skin peeling
  • Grade 2, moderate redness and swelling, skin thinning in the skin folds
  • Grade 3, skin thinning more than 1.5 centimeters across, not just on the skin folds, plus severe swelling
  • Grade 4, death of skin cells and deep skin ulcers

Sometimes, these effects can also develop weeks or years after radiotherapy has finished. This is called radiation recall.

In severe cases, the symptoms can restrict movement in the affected limb, which can interfere with day-to-day activities. People may find it difficult to wear clothes on the sensitized areas.

Source: Medical News Today

Thursday, 27 May 2021

Radiation side effects: Symptoms and management

 Radiation therapy, or radiotherapy, is a treatment that uses high doses of radiation to kill cancer cells and shrink tumors.

Though the radiation is targeted, it affects healthy cells as well as cancerous ones. For this reason, people undergoing radiation therapy (RT) can develop short- and long-term side effects during and after treatment.

This article describes common side effects of RT and provides tips for management and care.

External beam radiation

Internal radiation

Early side effects

Late side effects

These side effects can appear 6 months or longer after finishing RT and can include:

  • dry mouth and mouth sores
  • joint problems
  • thyroid problems
  • lymphedema, which is swelling in the arms or legs
  • infertility
  • secondary cancers

Wednesday, 26 May 2021

What to know about radiation therapy

 Radiation therapy is the term for treatment types that use radiation to destroy or shrink cancer cells and tumors.

The two main types of radiation therapy for treating cancer are external beam radiation and internal radiation therapy.

The type of radiation that a doctor recommends will depend on the type of cancer, the size and location of the tumor, and the person’s general health.

Radiation therapy may help meet different treatment goals. For instance, it may enhance the effectiveness of surgery, help prevent the spread of cancer, or relieve symptoms of advanced cancer.

This article discusses the different types of radiation therapy, including how they work and the side effects and risks. It also explains what a person can expect from radiation therapy and the likely outcome.

External beam radiation

Internal radiation therapy

Systemic radiation therapy

Systemic radiation therapy is another kind of internal radiation therapy.

It requires a person to swallow a radioactive substance, which travels throughout the body to find and kill the cancerous cells.

Alternatively, a healthcare professional may inject the radioactive substance into a person’s vein.

Source: Medical News Today

Tuesday, 25 May 2021

What to know about cancer

 Cancer causes cells to divide uncontrollably. This can result in tumors, damage to the immune system, and other impairment that can be fatal.

In the United States, an estimated 15.5 million people with a history of cancer were living as of January 1, 2016, according to a 2018 report from the American Cancer Society.

In this article, we examine types of cancer, how the disease develops, and the many treatments that help improve the quality of life and survival rates.

Cancer is a broad term. It describes the disease that results when cellular changes cause the uncontrolled growth and division of cells.

Some types of cancer cause rapid cell growth, while others cause cells to grow and divide at a slower rate.

Certain forms of cancer result in visible growths called tumors, while others, such as leukemia, do not.

Most of the body’s cells have specific functions and fixed lifespans. While it may sound like a bad thing, cell death is part of a natural and beneficial phenomenon called apoptosis.

A cell receives instructions to die so that the body can replace it with a newer cell that functions better. Cancerous cells lack the components that instruct them to stop dividing and to die.

As a result, they build up in the body, using oxygen and nutrients that would usually nourish other cells. Cancerous cells can form tumors, impair the immune system and cause other changes that prevent the body from functioning regularly.

Cancerous cells may appear in one area, then spread via the lymph nodes. These are clusters of immune cells located throughout the body.

Is cancer genetic?

Genetic factors can contribute to the development of cancer.

A person’s genetic code tells their cells when to divide and expire. Changes in the genes can lead to faulty instructions, and cancer can result.

Genes also influence the cells’ production of proteins, and proteins carry many of the instructions for cellular growth and division.

Some genes change proteins that would usually repair damaged cells. This can lead to cancer. If a parent has these genes, they may pass on the altered instructions to their offspring.

Some genetic changes occur after birth, and factors such as smoking and sun exposure can increase the risk.

Other changes that can result in cancer take place in the chemical signals that determine how the body deploys, or “expresses” specific genes.

Finally, a person can inherit a predisposition for a type of cancer. A doctor may refer to this as having a hereditary cancer syndrome. Inherited genetic mutations significantly contribute to the development of 5–10 percent of cancer cases.

Source: Medical News Today

Monday, 24 May 2021

Medical myths: All about cancer

 May is National Cancer Research Month, a time to highlight the ongoing work of scientists who dedicate their lives to understanding and treating cancer. Here, we cover 10 myths associated with cancer to help people cut through the maze of misinformation.

According to the World Health Organization (WHO), cancer accounted for 10 millionTrusted Source deaths worldwide in 2020. Globally, it is a leading cause of death.

In the United States, an estimated 39.5% of people will receive a cancer diagnosis within their lifetime.

Myths tend to develop around particularly prevalent conditions. It is no surprise, therefore, that people often misunderstand cancer.

“Cancer” is a generic term for a group of diseases that can affect any part of the body. This variety adds fuel to the fire of confusion.

In this article, we hope to dispel some myths and clarify this common and varied group of diseases.

Cancer is not a death sentence. Despite the sobering statistics quoted above, cancer is not always terminal.

As scientists understand cancer better and develop improved treatments, recovery rates continue to improve.

For instance, in January 2019, an estimated 16.9 million cancer survivors were living in the United States. In the United Kingdom, survival rates have doubled in the last 40 years.

It is also worth noting that survival rates vary significantly depending on the type of cancer. For instance, in the U.K., survival rates for testicular cancer are 98%, whereas survival rates for pancreatic cancer are just 1%.

According to the National Cancer Institute:

“In the United States, the likelihood of dying from cancer has dropped steadily since the 1990s. Now, 5-year survival rates for some cancers, such as breast, prostate, and thyroid cancers, are 90% or better. The 5-year survival rate for all cancers combined is currently about 67%.”

Overall, cancer death rates are slowly declining, although the survival rates of some cancers are increasing more than others. An annual report on the status of cancer in the U.S., which appears in Cancer in 2020, concludes:

“[C]ancer death rates decreased 1.5% on average per year during 2001 through 2017.”

This is a myth. Cancer is not contagious. Someone with cancer cannot spread it to others.

However, some sexually transmitted diseases, including human papillomavirus (HPV)Trusted Source and hepatitis B and C, can cause cancers in the cervix and the liver. In these cases, an infectious agent causes the cancer, but the cancer itself is not contagious.

As an interesting aside, scientists have documentedTrusted Source that cancers in some animals, including Tasmanian devils and dogs, can cause fatal transmissible cancers: devil facial tumor disease and canine transmissible venereal tumor, respectively.

Source: Medical News Today

Sunday, 23 May 2021

Cancer advances: Dr. William G. Nelson discusses genome sequencing and immunotherapy

 Dr. William G. Nelson is the director of the Johns Hopkins Kimmel Cancer Center, in Baltimore, MD, and a professor of oncology. In this article, he discusses two rapidly developing approaches to cancer treatment: Genome sequencing and immunotherapy.

Dr. Nelson is also the editor-in-chief of Cancer Today, the magazine of the American Association for Cancer Research (AACR). What follows is a lightly edited version of Dr. Nelson’s response when we asked him which areas of cancer research he was most excited about. He particularly focuses on data presented at this year’s AACR Annual Meeting, held virtually.

Cancer medicine is in the midst of a fast-paced transformation that is starting to produce clear improvements in disease outcomes, with cancer death rates down 27%Trusted Source over the past 20 years.

Some of the decline in cancer deaths can be attributed to smoking cessation and some to the broader adoption of established cancer screening approaches, but innovations arising from cancer research have really started to impact cancer care.

Genome sequencing

Researchers have long known that all cancers fundamentally arise as a consequence of acquired defects in genes and in gene function that propel rogue cells in the body to replicate wildly.

Now, with advances in genome sequencing technologies, all of the aberrant genes in any cancer can be inventoried, allowing existing treatment approaches to be tailored to individual cancer cases. This opens the door to the discovery and development of scores of new cancer treatments aimed directly at the products of defective genes.

For example, during the Clinical Trials Plenary Sessions at the AACR Annual Meeting 2021, researchers presented data from a phase 3 trial in patients with relapsed, slow-spreading non-Hodgkin lymphoma.

The researchers showed that combining the standard-of-care drug rituximab with copanlisib — a therapeutic that targets the PI3K cell-signaling pathway, which lymphoma cells rely on for survival — could reduce the risk of disease progression or death by half, compared with a placebo and rituximab.

In another trial, selpercatinib, a first-in-class, highly selective, and potent RET kinase inhibitor that is approved to treat some lung and thyroid cancers, showed promise for several other cancer types, including pancreatic cancer, colon cancer, and breast cancer.

Genome sequencing approaches are also increasingly used to detect cancer DNA shed into blood and body fluids, giving rise to what will be a new generation of cancer screening and monitoring tests.

Several presentations from the meeting showcased multicancer early detection tests that utilize machine learning and cell-free DNA from liquid biopsy samples to search for abnormal patterns of DNA methylation.

Source: Medical News Today