Regular
exposure to stress can impact our physical and mental health, but how does it
actually affect our brains? One new Harvard Medical School study answers that
question.
Stress
— especially when we experience it on a regular basis — takes a significant
toll on our minds and bodies.
It can make
us feel more irritable and constantly tired, and it impacts our ability to
focus.
Chronic stress can also interfere with our sleep
patterns, appetite, and libido, and it can also exacerbate a range of health
conditions.
These include
diabetes, heart disease, and gastrointestinal problems.
One study
that Medical News Today covered earlier this year, in fact, saw that
even minor levels of distress can increase a person's risk of chronic disease.
What impact
does stress have on the brain in physiological and cognitive terms? Researchers
from Harvard Medical School in Boston, MA, have explored this question and reported their answer in
the journal Neurology.
The stress hormone affects memory
In their
study, the researchers worked with participants with an average age of 49 and
no diagnosis of dementia.
At baseline,
the investigators asked each participant to undergo a psychological exam. They
also assessed each participant's memory and thinking abilities. For the purpose
of the study, they assessed these abilities again after an average period of 8
years.
Furthermore,
at the beginning of the study, all the volunteers provided blood samples. The
team collected them in the morning, after an appropriate fasting period, so
that the blood test results would be accurate.
Specifically,
the researchers were interested in measuring the participants' levels of blood
cortisol, which is a hormone released chiefly in response to stress. After
assessing cortisol levels, the investigators divided the participants into
groups according to their results.
They
categorized participants as having high, middle, or low levels of cortisol,
where middle levels corresponded to the normal cortisol level range of
10.8–15.8 micrograms per deciliter.
The
researchers found that people with high levels of blood cortisol had much
poorer memory when compared with peers with normal cortisol levels.
Importantly, impaired memory was present in these individuals even before
obvious symptoms of memory loss set in.
These results
remained consistent even after the investigators had adjusted for relevant
modifying factors, such as age, sex, smoking habit, and body mass index (BMI).
"Cortisol
affects many different functions," notes study author Dr. Justin B.
Echouffo-Tcheugui, from Harvard Medical School, "so it is important to
fully investigate how high levels of the hormone may affect the brain."
It is 'important to find ways to
reduce stress'
Also, 2,018
participants agreed to undergo MRI scans,
so that the researchers could measure their brain volumes. This allowed the
researchers to confirm that people with high cortisol levels also tended to
have lower total brain volumes.
Those in the
high-cortisol group had an average total cerebral brain volume of 88.5 percent
of total cranial volume versus 88.7 percent of total cranial volume in people
with regular cortisol levels.
As for low
cortisol levels, the researchers found no links at all between this and a
person's memory or their brain volume.
"Our
research detected memory loss and brain shrinkage in middle-aged people before
symptoms started to show," says Dr. Echouffo-Tcheugui.
"[S]o
it's important for people to find ways to reduce stress, such as getting enough
sleep, engaging in moderate exercise, incorporating relaxation techniques into
their daily lives, or asking their doctor about their cortisol levels and
taking a cortisol-reducing medication if needed."
Dr. Justin B.
Echouffo-Tcheugui
"It's
important for physicians to counsel all people with higher cortisol
levels," he adds. Still, the researchers admit that their study does have
some limitations — such as the fact that they only measured the participants'
blood cortisol levels once, which may not be representative of their long-term
exposure to this hormone.
Moreover,
they note that most of the study participants were of European descent, which
means that the findings may not accurately reflect the effects of stress on
other populations.
Source: Medical News Today