Friday, 28 February 2025

In Conversation: Why exercise is key to living a long and healthy life

 What should we do in order to live healthier lives for longer? Research shows there are a few lifestyle interventions that can effectively prolong our life and health span. One of these is exercise, but what kind, and in what combinations, and why does it help add years to our lives? Find out in our latest podcast episode.

Seemingly since times immemorial, humankind has been, metaphorically speaking, seeking the path that leads to the “Fountain of Youth” — that is ways to ensure a longer, healthier life.

And while we may not yet benefit of any “miracle” medicines or technologies to prolong our life spans well over the hundred-year mark, many recent studies have provided strong evidence in support of the notion that simple, achievable lifestyle changes can help us stay healthy for longer and decrease our risk of premature death.

Research presented at the American Heart Association’s Scientific Sessions 2023Trusted Source, for example, suggested that eight healthy habits can slow down biological aging by as much as 6 years.

These habits are related to diet, maintaining a healthy weight, avoiding tobacco, maintaining good sleep hygiene, managing cholesterol, blood sugar, and blood pressure, and, no less importantly, staying physically active.

In the latest instalment of our In Conversation podcast, Medical News Today explores the link between exercise and living a long and healthy life, in dialogue with Dr. Borja del Pozo Cruz and Dr. Edwina (Eddie) Brocklesby.

Dr. del Pozo Cruz is principal researcher in Applied Health Sciences at the University of Cadiz in Spain, and adjunct associate professor in the Department of Sports Science and Clinical Biomechanics at the University of Southern Denmark.

In collaboration with other researchers, Dr. del Pozo Cruz has conducted various studies exploring the link between different forms of exercise and the risk of death from different causes.

Dr. Brocklesby has gained fame under the nickname “Iron Gran,” as at the age of 72, she was the oldest British woman to complete an Ironman Triathlon. She is also founder and CEO of Silverfit, a not-for-profit organization promoting lifelong fitness.

In a study published in JAMA Internal MedicineTrusted Source in August 2023, Dr. del Pozo Cruz and his colleagues analyzed data from 500,705 participants followed up for a median period of 10 years to see how different forms of exercise related to a person’s mortality risk.

The study looked at the effect of moderate aerobic physical activity, such as walking or gentle cycling, vigorous aerobic physical activity, such as running, and muscle-strengthening activity, like weight lifting.

Its findings indicated that a balanced combination of all of these forms of exercise worked best for reducing mortality risk.

More specifically, around 75 minutes of moderate aerobic exercise, plus more than 150 minutes of vigorous exercise, alongside at least a couple of strength training sessions per week were associated with a lower risk of all-cause mortality.

When it came to reducing the risk of death linked to cardiovascular disease specifically, Dr. del Pozo Cruz and his collaborators suggested combining a minimum of 150–225 minutes of moderate physical activity with around 75 minutes of vigorous exercise, and two or more strength training sessions per week.

Dr. Brocklesby, who goes by “Eddie,” is herself an example of the importance of combining different forms of exercise. Indeed, training and participating in a triathlon — which is an endurance multisport race where participants compete in swimming, cycling, and running — involves achieving a balanced “diet” of moderate and vigorous exercise, as well as strength training.

But what about people who are not nearly as athletic? What is the minimum “amount” of exercise that could help fend off some of the conditions that pose the highest threat to health?

Dr. del Pozo Cruz and his team may also have found an answer to this question. In December 2022, they published the findings to a previous study in the European Heart Journal.

This research suggested that engaging in vigorous exercise for only 2 minutes a day could help slash the risk of death related to cancer or cardiovascular events.

The researchers found that study participants who never engaged in vigorous exercise had a 4% risk of dying within 5 years, but introducing less than 10 minutes of vigorous activity weekly halved this risk. Moreover, their risk of death halved again for those who engaged in at least 60 minutes of exercise per week.

In our podcast, Dr. del Pozo Cruz emphasized that almost any amount of any form of exercise is better than none, a point reinforced by a new study arguing that any activity at all is better for heart health than a sedentary lifestyle.

However, he also cautioned that physical activity related to chores or to one’s job, as opposed to exercise in a leisure context, may sometimes do more harm than good.

Once again, his idea is supported by recently published research, which found a link between physically demanding occupations and a higher risk of cognitive impairment.

Some of the most common occupations linked to intensive physical activity cited in this research were in nursing and care, retail, and farming, where individuals are on their feet a lot, and often having to deal with stressful situations.

So while all forms of exercise can be good for health, strenuous or intensive physical activity in a work environment could end up compounding the risk of various health conditions.

And even exercise for leisure can affect aspects of physical health — such as joint integrity — particularly later in life. In our podcast, both Dr. del Pozo Cruz and Eddie emphasized the importance of consulting a trusted healthcare provider, who can advise on the best forms of exercise to engage in on an individual basis.

To find out more about how and why different forms of exercise can support longevity, and to hear the story of how Edwina became “Iron Gran,” listen to our podcast episode in full below or on your preferred streaming platform.

Source - Medical News Today

Thursday, 27 February 2025

What to know about the Blue Zone diet and other healthy habits for longevity

 The question of how to live a long, healthy life is increasingly at the forefront of medical research. While centuries ago some may have turned to finding mythical immortality-granting items like the Holy Grail, scientists now say that achieving longevity may rely on eating the right foods, adopting healthy habits, and remaining socially active.

Reaching your hundredth birthday means you become a member of a “special club” of centenariansTrusted Source. While researchers believe the number of centenarians was very low before 1900, today many more people are able to reach this ripe old age.

As of 2021, there were an estimated 573,000 centenarians globally. The United Nations expects that number to jump rapidly, with a reported estimate of 3.7 million by 2050.

What do centenarians do to help them reach triple-digit birthdays — what is their secret? Medical News Today spoke with six experts to find out what the “secret sauce” behind longevity is.

In 2016, National Geographic Fellow Dan Buettner and his team published a studyTrusted Source on what they found to be the secrets to longevity.

Dubbed the Blue Zones, Buettner identified five specific areas of the world where people consistently live over 100 years of age. These areas are:

  • Sardinia, ItalyTrusted Source
  • Ikaria, GreeceTrusted Source
  • Nicoya, Costa RicaTrusted Source
  • Loma Linda, CaliforniaTrusted Source
  • Okinawa, JapanTrusted Source.

“These are places where human beings have lived manifestly longest,” Buettner explained to Medical News Today. “They’ve achieved the health outcomes we want: long lives largely free of chronic diseaseTrusted Source. Since only 80% of how long we live is dictated by disease, these people’s lifestyles and environments offer us instructions and clues for how we can set up our lives to live longer.”

Within these five areas, Buettner discovered there were nine common practices that people followed that might explain their slower aging process. Called the Power 9, they include:

  • move naturally
  • have a purposeTrusted Source in life
  • reduce stress
  • practice the 80% diet rule, which is to stop eating when 80% full
  • favor a plant-based diet
  • drink alcohol in moderate amounts
  • belong to a communityTrusted Source
  • put family first
  • keep a social circle that supports healthy behaviors.

Loneliness, said Buettner, is a top risk factor for a shorter life, so preventing that as much as we can could help add years to our lives:

“We know that lonely people are expected to live 8 fewer years than well-connected people and that health behaviors [are] measurably contagious. People in Blue Zones are in socially connected villages with strong social ties, which gives them a longevity edge from the very beginning.”

“There’s no short-term fix [or] supplement for longevity,” he added. “Learn plant-based dishes that you like and cook at home. Curate a social circle of three to five healthy friends [who] will care about you on a bad day. Health behaviors are contagious, and friends tend to be long-term adventures.”

As diet makes up a few of the Power 9 learned from Blue Zones, Buettner has also launched the Blue Zone Food Guidelines that feature 11 recommendations reflecting how the world’s longest-living people ate for most of their lives.

“If you want to know what a centenarian [did to live] to be 100, you have to know what they ate during their whole [life],” he said. “Working with Harvard for my book The Blue Zones Kitchen, we collected 155 dietary studies done in all Blue Zones over the past 80 years and averaged them.”

“It was clear that over 90% of their traditional dietary intake came from whole food, plant-based sources [and] was about 65% complex carbs,” noted Buettner. “The pillars of every longevity diet in the world are whole grains, nuts, greens, and other garden vegetables, tubersTrusted Source, and beans.”

Dr. Valter Longo, Edna M. Jones Chair in Gerontology and professor of gerontology and biological sciences at the USC Leonard Davis School of Gerontology, developed the Longevity DietTrusted Source after years of research into aging, nutrition, and disease.

“The Longevity Diet, based on [the] five pillars of longevity, entails all of the everyday and periodic dietary habits that are associated with increased longevity and healthspan,” he explained to MNT.

The main facets of the Longevity Diet include:

  • eating a low-protein pescatarian diet until the age of 65–70 years, followed by moderate proteins later in life
  • fasting for 12 hours every night
  • doing, on average, three cycles of a fasting-mimicking diet per year, each lasting 5 days.

“Because diet [is] intended as ‘how and what we eat’ and not as a method to lose weight, [it] can regulate the genes that regulate the aging process, but also those that regulate the removal of damaged components of cells and the regeneration of parts of various tissues and organs,” Dr. Longo added.

Additionally, previous research suggests that the Mediterranean diet can also provide benefits when it comes to longevity.

A review published in January 2020 concluded that the Mediterranean diet helps slow downTrusted Source the progression of aging and the onset of frailtyTrusted Source in older age.

And research published in March 2021 says adhering to the Mediterranean diet may add yearsTrusted Source to a person’s life.

Why is diet so important for longevity?

According to Monique Richard, a registered dietitian nutritionist, owner of Nutrition-In-Sight in Johnson City, TN, and national media spokesperson for the Academy of Nutrition and Dietetics, when it comes to eating for longevity, diets like the Blue Zone Diet, Longevity Diet, and Mediterranean diet stand out because of the lifestyle components they share.

“Examples of commonalities observed within these populations include more families and individuals growingTrusted Source and consuming their food [and] eating more whole foods, as in closest to what Mother Nature has made versus derived from a manufacturing plant, industrial farm, or fast food chain,” she explained to MNT.

“Overall intake and composition of these diets include less highly-processed foods, therefore often automatically decreasing levels of sodium, artificial flavors, colorings, and preservatives, fats or added sugar.” Richard noted.

“These dietary patterns often include foods lower in saturated fats, cholesterol, and calories, including more foods that are richer in nutrients such as fiber, antioxidants like vitamin C, E, A, [and] http://B, and higher in minerals such as potassium, magnesium, and iodine.”

– Monique Richard

When looking to make diet changes to increase longevity, Richard said it is not just about extending life, but also about increasing its quality.

She suggested:

  • take inventory of what food you have on hand and what should be added or subtracted
  • reassess your sugary beverageTrusted Source intake
  • examine how much animal-derived meats and other foods you are eating and consider alternatives
  • cook more at home
  • take the time to shop for groceries rather than using a delivery system
  • plant herbs in pots or cartons on a window sill or small deck if you do not have a garden space to cultivate them
  • shop at the farmer’s market
  • experiment with “new to you” foods
  • brighten up dishes with herbs and spices
  • add more greens, beans, lentils, and vegetables into your daily diet
  • take time to celebrate food.

“The emphasis is not on restriction or negative consequences, but leaning into true quality, consistency, and overall health with a pillar of foundational pure, wholesome factors,” Richard said.

“Don’t forget to slow down with eating, with chewing, with making or creating a meal, with making time to stop and smell the flowers, [and] with making long-lasting meaningful changes,” she added.

Wednesday, 26 February 2025

In Conversation: Can we really ‘outrun the Grim Reaper’?

 Does putting the human body under a lot of stress, such as in professional sprinting or long-distance running, impact life span? Is there such a thing as too much exercise or too intense? This podcast episode aims to find the answer to the question, “Can extreme exercise prolong our longevity?” and more.

Everything in moderation, or “pan metron ariston,” as the ancient Greek saying goes. And when it comes to matters of health, a similar philosophy is often touted as the best strategy — whether this be nutrition or exercise.

More and more research shows that staying active is the key to a longer, healthier lifeTrusted Source. But what about intense physical activity? Could professional athletic performance do more harm than good? Or can this intense training actually contribute to an increased life span?

In this episode of In Conversation, we turn the focus to all things extreme exercise and longevity. Based on the findings of a recent study, which found that a select group of elite runners could live around five years longer on average than the general population, Medical News Today editors Maria Cohut and Yasemin Nicola Sakay discuss the probable biological mechanisms behind how more extreme forms of exercise, such as 4-minute mile running, affect longevity with an expert in cardiology.

Joining the conversation is Michael Papadakis, MD, MRCP (UK), president of the European Association of Preventive Cardiology (EAPC), professor of cardiology at St George’s, University of London, honorary consultant cardiologist at St George’s University Hospitals National Health Service Foundation Trust, and consultant cardiologist at Cleveland Clinic London in the United Kingdom.

Papadakis shares easy-to-follow advice on how to incorporate more physical activity into our daily lives while discussing the potential health risks and benefits of running and similar forms of professional athletic performance.

Source - Medical News Today

Tuesday, 25 February 2025

Daily omega-3 supplements and regular exercise may slow aging

 

  • A new study suggests that omega-3 and vitamin D supplements, when combined with regular exercise, may help slow biological aging by several months over a 3-year period.
  • Researchers analysed data from the DO-HEALTH trial, which tracked over 700 older adults and found that those who followed this regimen experienced measurable benefits at the molecular level.
  • The researchers said that even though the effects might seem small, they could still make a big difference for public health — helping to lower the risk of age-related health issues and improving the well-being of older adults.

According to new research, regularly taking omega-3 and vitamin D supplements can support health and mitigate aging-related issues.

In the study published in Nature AgingTrusted Source, researchers reported that taking these supplements over 3 years slowed biological aging by 3 to 4 months, with even greater effects observed when combined with exercise.

They explained that biological aging happens at the molecular level, so even if two people are the same age, their bodies may age at different speeds depending on their overall health.

Although a reduction of a few months in biological aging may seem modest, the researchers said this could have meaningful public health benefits, including a lower prevalence of certain age-related conditions.

The researchers analysed data from the DO-HEALTH trial, which examined the impact of supplements and exercise on older adults across five European countries between 2012 and 2014.

They reviewed information from over 700 participants aged 70 and older, who were assigned either a placebo or omega-3, vitamin D, and exercise alone or in combination.

All participants were based in Switzerland, and approximately half were in good health, without major chronic illnesses or disabilities.

To assess biological aging, blood samples were collected at the beginning and end of the study and analysed using four biological clocks.

First author Heike A. Bischoff-Ferrari, MD, MPH, DrPH from the University of Basel Department of Aging Medicine FELIX PLATTER, and the University of Zurich’s Department of Geriatrics and Aging Research, Switzerland, explained the key findings to Medical News Today.

“In our prior studies in the same trial (DO-HEALTH) of generally healthy adults age 70 and older, we found omega-3 lowered the rate of falls by 10% and reduced the rate of infections by up to 13%Trusted Source, while omega-3, vitamin D and exercise combined lowered the risk of pre-frailty by 39% and invasive cancer by 61%,” Bischoff-Ferrari told us.

“Given these health benefits, we explored whether these treatments also translated to slowing of biological aging. For this we studied the most reliable molecular markers of biological age: epigenetic clocks,” she told us.

“Our findings provide a strong signal that omega-3 supplementation (1 [gram per day] algae-based) slows biological aging in humans, and that the combination vitamin D and exercise may make this effect even stronger. Biological age was slowed by 3-4 months in 3 years.”

– Heike A. Bischoff-Ferrari, MD, MPH, DrPH

 Changes in DNA methylation key to measuring aging

The researchers explained that these clocks measure biological aging by tracking changes in DNA methylation, specifically the addition and removal of methyl groups.

They also noted that using multiple DNA methylation clocks was a key strength of the study, as each clock captures different aspects of the aging process.

One of the biological clocks used in the study, PhenoAge, indicated that older adults who took 1 gram of polyunsaturated omega-3 fatty acids from algae, combined with vitamin D (2,000 international units per day) and 30 minutes of exercise three times a week, slowed biological aging by approximately 2.9 to 3.8 months over 3 years.

While omega-3 alone reduced biological aging in three of the epigenetic clocks analysed, the combination of all three interventions had an even greater impact.

“To date, one of the most critical questions in the field of slowing biological aging is whether a treatment exists that can effectively rejuvenate humans not just mice,” Bischoff-Ferrari said.

“Our findings provide a strong signal that omega-3 slows biological aging in humans, and that the combination vitamin D and exercise may make this effect event stronger. While the effects documented (3-4 months rejuvenation of biological age) appear small, if sustained, may have relevant effects on population health.”

– Heike A. Bischoff-Ferrari, MD, MPH, DrPH

Steve Horvath, PhD, another lead researcher involved, said that “the results in DO-HEALTH for the prevention of infections, falls, cancer and pre-frailty translated to slowing biological aging in the same trial.”

“This supports these three public health strategies as a combined solution at the public health level to extend health span in older adults. Further, these strategies are affordable and safe as shown in DO-HEALTH over a 3-year follow-up,” Horvath explained.

“As a next step,” he told us, “we plan to use DO-HEALTH as a validation platform for novel measures of biological aging and just built the global health span extension consortium to advance the concept of combining feasible life-style changes that play on different mechanistic pathways of biological aging and become powerful in combination.”

The researchers noted that although the treatments slowed down aging at the molecular level, there is no clear proof that this leads to a longer life or better health.

In addition, previous findings from the DO-HEALTH trial showed that omega-3 supplementation reduced the risk of falls by 10% and infections by up to 13% compared with those who did not take the supplement.

Further research has also suggested that a combination of omega-3, vitamin D, and exercise may lower the risk of cancer.

With this in mind, some experts have cautioned against drawing broad conclusions from the findings, as further research is needed.

Clifford Segil, DO, a neurologist at Providence Saint John’s Health Center in Santa Monica, CA, not involved in this research, told MNT that “he likes to see studies which test combination vitamin therapies for health and in clinical practice vitamin D is often given with calcium.”

“I enjoyed seeing these researchers try to determine if Vitamin D with omega-3 improved biological age with exercise. I would have like to see the study broken into 3 parts which would have been biological age affects from Vitamin D and omega 3 supplementation. A second part confirming how much exercise decreased biological age with new next generation tests. And then a third part to confirm that both together worked better than alone.”

– Clifford Segil, DO

What do these findings mean for patients? While further research is needed, tried and tested strategies can still be implemented.

“Everyone should consider exercising as we age as it will help us stay young,” Segil said. “I often tell my patients that ‘if you don’t use it, you will lose it’.”

However, “using the right combination of supplements may be helpful and someday the use of supplements may be evidence based,” the physician suggested.

Source - Medical News Today